Influence of Neuromuscular Fatigue Accumulated During Training on Subsequent Chronic Adaptations: PROTECT-10
Healhty
What this study involves
The registry does not currently label this study as recruiting. Ask about its status before planning a screening visit.
- Study type
- Interventional
- Phase
- Not applicable
- Age range
- 18 years - 45 years
- Sex eligible
- All sexes
- Healthy volunteers
- Accepted
- Participants
- 58 Estimated
These are starting points, not an eligibility decision. The research team must review the full requirements.
About the research
A 13-week longitudinal experimental study designed to determine how the level of neuromuscular fatigue induced by strength training influences chronic adaptations. Four assessment periods (pre-protocol, mid-point 1, mid-point 2, and post-protocol) will be used to measure neuromuscular, physiological, and structural parameters. A reference group will be included to assess measurement variability across the evaluation phases (this group will only undergo these assessments), while an experimental group will follow a standardized training protocol (in addition to the assessment phases).
Read the full description
Physical training is based on the dose-response principle, whereby the applied load determines the resulting adaptations. However, a higher dose does not consistently lead to greater gains (Hass et al., 2000; Mitchell et al., 2012), and the precise role of neuromuscular fatigue in chronic adaptations remains a subject of debate. Some studies suggest that fatigue-specifically peripheral fatigue, which directly reflects metabolic disturbances within the muscle-serves as a key stimulus for promoting neuromuscular adaptations (Rooney et al., 1994), while others have observed no significant effect (Folland et al., 2002). These discrepancies can be attributed to several factors: the lack of precise quantification of fatigue; the failure to distinguish between central and peripheral fatigue (the latter being a critical factor) (Hureau et al., 2022); and the failure to account for differences in fatigability between men and women (Hunter, 2016). Furthermore, recent research indicates that peripheral fatigue is regulated at an individual threshold by the tone of type III-IV muscle afferents, which modulate the central motor drive to limit the accumulation of fatigue (Amann et al., 2015; Hureau et al., 2016). Gaining a better understanding of how this threshold-along with its sensitivity and potential plasticity through training-influences the adaptive response is essential for optimizing exercise prescription, both for performance and for health.
Who may be able to participate?
The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.
Inclusion Criteria:
- Man or woman between 18 and 45 years of age
- Active lifestyle (assessed via the GPAQ-2 questionnaire, with a minimum threshold defined as 600 MET-minutes per week)
- Capable of understanding the objectives and risks associated with the research and providing informed consent-dated and signed-in the judgment of the investigator
- Affiliated with a social security scheme
Exclusion Criteria:
- Known neurological, neuromuscular, cardiovascular, respiratory, or psychiatric condition
- Minors, adults under legal protection, or individuals unable to provide informed consent personally; high-level athletes or those undergoing strength-based training
- Pregnant or breastfeeding women
- Individuals in an emergency situation
Treatment, groups and participation
The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.
- Assignment
- Not randomized
- Masking
- No masking
Reference
This group will undergo only the assessment periods, without participating in the training program. It will allow for the monitoring of variations related to the passage of time, the repetition of tests, and measurement variability. This group will thus serve as a reference, and its results will be compared with those of the experimental group in order to estimate the actual effects of the training and to distinguish between "responders" and "non-responders" (Padilla et al., 2020; Bossi \& Mata, 2025).
experimental
This group will benefit from training sessions in addition to assessments.
Other: Trainig sessions
Trainig sessions OTHER
3 training periods, each consisting of two training sessions per week.
What researchers are measuring
Outcome measures describe what is being studied. They are not proof that a treatment works.
Primary measures
maximal isometric strength
Time frame: 3 weeks after the intervention
Determine the change in the maximal isometric strength of the right knee extensors following the entire training program.
Review the complete result tables and limitations in the official record.
Open official results ↗Research locations (1)
The overall study status and a local site’s status can differ. Confirm that location’s availability before traveling.
1 locations
CEERIPEStrasbourg, FranceStatus unknown
Study team and timeline
- Lead sponsor
- Centre Paul Strauss
- Study start
- Nov 3, 2026 Estimated
- Primary completion
- May 3, 2028 Estimated
- Study completion
- May 3, 2028 Estimated
- First posted
- Nov 10, 2026 Actual
- Last updated
- Nov 10, 2026 Actual
Official study contacts
No central contact is listed. Check the locations and the official record.
Official study title
Influence of Neuromuscular Fatigue Accumulated During Training on Subsequent Chronic Adaptations: PROTECT-10
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Source: ClinicalTrials.gov API v2. Information is submitted by sponsors and investigators. NLM does not approve the safety or science of all listed studies. Registry disclaimer.
Retrieved: Nov 12, 2026 · Last registry update: Nov 10, 2026