Influence of Neuromuscular Fatigue Accumulated During Training on Subsequent Chronic Adaptations: PROTECT-10
Healhty
De qué trata este estudio
El registro no identifica actualmente este estudio como reclutando. Consulta su estado antes de planificar una evaluación.
- Tipo de estudio
- De intervención
- Fase
- No aplica
- Rango de edad
- 18 años - 45 años
- Sexo admitido
- Todos los sexos
- Voluntarios sanos
- Aceptados
- Participantes
- 58 Estimado
Estos son puntos de partida, no una decisión de elegibilidad. El equipo debe revisar todos los requisitos.
Las explicaciones y la navegación están en español. Los textos proporcionados por el registro, incluidos títulos, resúmenes y criterios, se conservan en su idioma original. Puedes pedir orientación en español a WCR.
Acerca de la investigación
A 13-week longitudinal experimental study designed to determine how the level of neuromuscular fatigue induced by strength training influences chronic adaptations. Four assessment periods (pre-protocol, mid-point 1, mid-point 2, and post-protocol) will be used to measure neuromuscular, physiological, and structural parameters. A reference group will be included to assess measurement variability across the evaluation phases (this group will only undergo these assessments), while an experimental group will follow a standardized training protocol (in addition to the assessment phases).
Leer la descripción completa
Physical training is based on the dose-response principle, whereby the applied load determines the resulting adaptations. However, a higher dose does not consistently lead to greater gains (Hass et al., 2000; Mitchell et al., 2012), and the precise role of neuromuscular fatigue in chronic adaptations remains a subject of debate. Some studies suggest that fatigue-specifically peripheral fatigue, which directly reflects metabolic disturbances within the muscle-serves as a key stimulus for promoting neuromuscular adaptations (Rooney et al., 1994), while others have observed no significant effect (Folland et al., 2002). These discrepancies can be attributed to several factors: the lack of precise quantification of fatigue; the failure to distinguish between central and peripheral fatigue (the latter being a critical factor) (Hureau et al., 2022); and the failure to account for differences in fatigability between men and women (Hunter, 2016). Furthermore, recent research indicates that peripheral fatigue is regulated at an individual threshold by the tone of type III-IV muscle afferents, which modulate the central motor drive to limit the accumulation of fatigue (Amann et al., 2015; Hureau et al., 2016). Gaining a better understanding of how this threshold-along with its sensitivity and potential plasticity through training-influences the adaptive response is essential for optimizing exercise prescription, both for performance and for health.
¿Quién podría participar?
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Inclusion Criteria:
- Man or woman between 18 and 45 years of age
- Active lifestyle (assessed via the GPAQ-2 questionnaire, with a minimum threshold defined as 600 MET-minutes per week)
- Capable of understanding the objectives and risks associated with the research and providing informed consent-dated and signed-in the judgment of the investigator
- Affiliated with a social security scheme
Exclusion Criteria:
- Known neurological, neuromuscular, cardiovascular, respiratory, or psychiatric condition
- Minors, adults under legal protection, or individuals unable to provide informed consent personally; high-level athletes or those undergoing strength-based training
- Pregnant or breastfeeding women
- Individuals in an emergency situation
Tratamiento, grupos y participación
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- Asignación
- Sin asignación al azar
- Enmascaramiento
- Sin enmascaramiento
Reference
This group will undergo only the assessment periods, without participating in the training program. It will allow for the monitoring of variations related to the passage of time, the repetition of tests, and measurement variability. This group will thus serve as a reference, and its results will be compared with those of the experimental group in order to estimate the actual effects of the training and to distinguish between "responders" and "non-responders" (Padilla et al., 2020; Bossi \& Mata, 2025).
experimental
This group will benefit from training sessions in addition to assessments.
Other: Trainig sessions
Trainig sessions OTHER
3 training periods, each consisting of two training sessions per week.
Qué evalúan los investigadores
Estas medidas indican qué se estudia. No prueban que un tratamiento funcione.
Medidas principales
maximal isometric strength
Plazo: 3 weeks after the intervention
Determine the change in the maximal isometric strength of the right knee extensors following the entire training program.
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Abrir resultados oficiales ↗Centros de investigación (1)
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1 centros
CEERIPEStrasbourg, FranceEstado desconocido
Equipo y fechas
- Patrocinador principal
- Centre Paul Strauss
- Inicio del estudio
- 3 nov 2026 Estimado
- Finalización primaria
- 3 may 2028 Estimado
- Finalización del estudio
- 3 may 2028 Estimado
- Primera publicación
- 10 nov 2026 Real
- Última actualización
- 10 nov 2026 Real
Contactos oficiales del estudio
No hay un contacto central indicado. Revisa los centros y el registro oficial.
Título oficial del estudio
Influence of Neuromuscular Fatigue Accumulated During Training on Subsequent Chronic Adaptations: PROTECT-10
Consulta a Wellness Clinical Research
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Fuente: API v2 de ClinicalTrials.gov. Patrocinadores e investigadores envían la información. La NLM no aprueba la seguridad ni la ciencia de todos los estudios registrados. Aviso del registro.
Consultado: 12 nov 2026 · Última actualización del registro: 10 nov 2026