Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function

What this study involves

The registry says this study is recruiting. Individual locations may have different availability.

Study type

Interventional

Phase

Not applicable

Age range

18 years - Not specified

Sex eligible

All sexes

Healthy volunteers

Not accepted

Participants

144 Estimated

These are starting points, not an eligibility decision. The research team must review the full requirements.

About the research

This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.

Who may be able to participate?

The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.

Inclusion Criteria:

• Age ≥18 years
• Resting SBP ≥120 mmHg as measured during screening 1 \& 2
• Free from serious CV or metabolic diseases as identified by self-report and blood chemistry analysis.
• No contraindications to IMST (recent abdominal surgery, ruptured eardrum, asthma with very low symptom perception, fractured ribs, or pneumothorax)
• Language: English-speaking, with ability to comprehend study materials and instructions.
• Pre-visit Compliance: Willing to comply with pre-visit instructions (avoiding food and caffeine ≥ 3 hours, vigorous exercise, alcohol, and non-prescribed medications ≥ 24 hours) prior to each measurement visit.
• Lifestyle: Non-smokers (defined as self-report of not smoking cigarettes or vaping over the past year).

Exclusion Criteria:

• Self-report of history of cardiovascular disease, or conditions affecting the ear (e.g., ruptured eardrum).
• Recent abdominal surgery or presence of an abdominal hernia.
• Asthma with very low symptom perception, frequent severe exacerbations, or abnormally low perception of dyspnea.
• Ruptured eardrum or any other condition of the ear.
• Markedly elevated left ventricular end-diastolic volume and pressure.
• Current respiratory conditions such as a cold, sinusitis, or respiratory tract infection (participants may be included once they recover from the respiratory condition).
• Female-Specific: Pregnant or planning to become pregnant during the study period.
• Compliance: Unable or unwilling to comply with pre-visit restrictions (e.g., avoiding caffeine, alcohol, and exercise within specified hours before visits).

Treatment, groups and participation

The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.

Assignment

Random assignment

Masking

No masking

What researchers are measuring

Outcome measures describe what is being studied. They are not proof that a treatment works.

Primary measures

Research locations (1)

The overall study status and a local site’s status can differ. Confirm that location’s availability before traveling.

1 locations

Study team and timeline

Lead sponsor

University of Minnesota

Study start

Oct 24, 2025 Actual

Primary completion

Mar 31, 2027 Estimated

Study completion

Mar 31, 2027 Estimated

First posted

Aug 7, 2025 Actual

Last updated

Nov 10, 2026 Actual

Official study contacts