The Comparison of Tunnel Morphology and Graft Healing in Anterior Cruciate Ligament Reconstructions Using Peroneus Longus And Hamstring Tendons
Anterior Cruciate Ligament Rupture
What this study involves
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- Study type
- Interventional
- Phase
- Not applicable
- Age range
- 18 years - 45 years
- Sex eligible
- All sexes
- Healthy volunteers
- Not accepted
- Participants
- 58 Actual
These are starting points, not an eligibility decision. The research team must review the full requirements.
About the research
1. Comparison of the grafts using Magnetic Resonance Imaging (MR) to determine whether their maturation and bone integration are different,
2. Comparison of the grafts using Computerized Tomography (CT) to determine whether their effects on the tunnels opened in cruciate ligament reconstruction surgeries are different,
3. In the event that graft healing and effects on the tunnels differ between grafts, determination of whether these differences are related to patient clinics,
Read the full description
The project method; Patients who will be operated with 2 different grafts used in anterior cruciate ligament surgeries will be included in 2 different randomized groups of 29 people (hamstring and peroneus groups) determined by obtaining their informed consent before the surgery and then,
1. The maturation of the grafts will be measured and compared with the SNQ (Signal/Noise quotient) value and the graft-bone integration with the measuring Tendon Bone Healing Grade with the Magnetic Resonance (MR) to be taken at the 1st year controls after the surgery,
2. Changes in tunnel morphology; The volume of the tunnels will be measured with the Computerized Tomography (CT) imaging method to be taken prospectively within the first week after the surgery date and 1 year after the surgery date and the changes within 1 year will be calculated by comparing them.
3. In the outpatient clinic follow-ups of both groups; Knee laxity will be obtained with Lachman, Anterior drawer and Pivot shift tests and knee scores and activity levels will be obtained using IKDC, Lysholm, Marx activity scales and it will be examined whether these data are related to SNQ, Tendon Bone Healing Grade and tunnel expansion.
Who may be able to participate?
The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.
Inclusion Criteria:
- Patients aged between 18 and 45 years.
- BMI in the range of 18 to 28.
- Diagnosed with an anterior cruciate ligament (ACL) injury preoperatively confirmed by MRI.
- Patients for whom it is deemed appropriate to harvest ipsilateral hamstring tendons or Peroneus Longus tendon for use as a graft.
Exclusion Criteria:
- History of previous surgery on the affected knee or ankle.
- Presence of multiple ligament injuries in the affected knee.
- ACL injuries that occurred more than 12 months prior to surgery.
- Evidence of unstable meniscal injury on preoperative MRI that may alter the -postoperative rehabilitation protocol.
- Inability to obtain a graft diameter of at least 9 mm using the isolated graft.
- Presence of meniscal tears requiring repair.
- Presence of advanced chondral lesions requiring surgical intervention.
- Intraoperative detection of multiple ligament injuries.
- Requirement for additional surgical procedures that would alter the standard rehabilitation protocol.
- Occurrence of intraoperative surgical complications.
Treatment, groups and participation
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- Assignment
- Random assignment
- Masking
- Single masked
Peroneus Longus Group
Participants who underwent ACL reconstruction using Peroneus Longus tendon graft.
Procedure: Surgical procedure using Peroneus Longus for ACL reconstruction.
Hamstring Group
Participants who underwent ACL reconstruction using Hamstring tendon graft.
Procedure: Surgical procedure using Hamstring tendons for ACL reconstruction.
Surgical procedure using Peroneus Longus for ACL reconstruction. PROCEDURE
Surgical procedure using Peroneus Longus for ACL reconstruction.
Surgical procedure using Hamstring tendons for ACL reconstruction. PROCEDURE
Surgical procedure using Hamstring tendons for ACL reconstruction.
What researchers are measuring
Outcome measures describe what is being studied. They are not proof that a treatment works.
Primary measures
Graft Maturation Assessed by Signal-to-Noise Quotient (SNQ) on MRI
Time frame: 1 year postoperatively.
Comparison of graft maturation between peroneus longus and hamstring tendon autografts using SNQ values obtained from 1-year postoperative MRI.
Tendon-Bone Healing Assessed by MRI Grading System
Time frame: 1 year postoperatively.
Comparison of graft-bone integration between peroneus longus and hamstring tendon autografts using MRI Grading System obtained from 1-year postoperative MRI.
Change in Tunnel Volume Assessed by CT
Time frame: Within 1 week post-surgery and at 1 year post-surgery.
Comparison of tunnel volume changes between peroneus longus and hamstring tendon autografts by measuring tunnel volume via CT imaging performed within the first week and 1 year after surgery.
Secondary measures
Knee Laxity Assessed by Clinical Tests
Time frame: At 1-year follow-up.
Comparison of knee laxity (Lachman, anterior drawer, and pivot shift tests) between groups and correlation with graft healing (SNQ, Tendon bone healing grade) and tunnel expansion.Clinical grading of laxity based on standard examination protocols.
Patient-Reported Knee Function and Activity Levels
Time frame: At 1-year follow-up.
Comparison of knee function and activity levels between groups using IKDC, Lysholm, and Marx scales and evaluation of correlations with SNQ, Tendon bone healing grade, and tunnel volume changes.Standardized scoring from IKDC, Lysholm, and Marx Activity scales.
Relationship Between Tunnel Changes and Clinical Outcomes
Time frame: At 1-year follow-up.
Assessment of whether tunnel volume changes correlate with knee function, activity levels, or laxity test results.Statistical correlation analysis between tunnel volume changes and clinical outcomes.
Comparison of Graft Healing and Tunnel Changes Between Groups
Time frame: 1 year postoperatively.
Evaluation of whether differences in SNQ, Tendon bone healing grade, or tunnel volume changes are specific to patient demographics or clinical characteristics.
Review the complete result tables and limitations in the official record.
Open official results ↗Research locations (1)
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1 locations
Karadeniz Technical University, Orthopedic and Traumatology DepartmentTrabzon, Turkey (Türkiye)Status unknown
Study team and timeline
- Lead sponsor
- Karadeniz Technical University
- Study start
- Jan 1, 2025 Actual
- Primary completion
- Jun 1, 2026 Actual
- Study completion
- Jun 1, 2026 Actual
- First posted
- Jan 10, 2025 Actual
- Last updated
- Nov 10, 2026 Actual
Official study contacts
No central contact is listed. Check the locations and the official record.
Official study title
The Comparison of Tunnel Morphology and Graft Healing in Anterior Cruciate Ligament Reconstructions Using Peroneus Longus And Hamstring Tendons
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Source: ClinicalTrials.gov API v2. Information is submitted by sponsors and investigators. NLM does not approve the safety or science of all listed studies. Registry disclaimer.
Retrieved: Nov 12, 2026 · Last registry update: Nov 10, 2026