rTMS Treatment in Vascular Parkinsonism
Vascular Parkinsonism
What this study involves
The registry does not currently label this study as recruiting. Ask about its status before planning a screening visit.
- Study type
- Interventional
- Phase
- Not applicable
- Age range
- 18 years - 90 years
- Sex eligible
- All sexes
- Healthy volunteers
- Not accepted
- Participants
- 0 Actual
These are starting points, not an eligibility decision. The research team must review the full requirements.
cannot enroll the participants
About the research
Vascular parkinsonism (VP), parkinsonism resulting from ischemic cerebrovascular disease, was suggested in 1929. The main features are wide-based gait, postural instability, and falls, which make patients with VP frustrated. Currently, the treatment is challenging.
Transcranial magnetic stiumation is a noninvasive procedure using electromagnetic induction to stimulate brain, and repetitive transcranial magnetic stiumation (rTMS) can selectively change brain activity to enhance desired effects. The aim of this study is to explore the therapeutic effect of rTMS for the VP.
Read the full description
1. Primary outcome
\- The number of steps
2. Secondary outcome
- UPDRS part III - motor part
- Finger tapping test with right hand
- The completion time during the SWS test
- Freezing episodes of gait trajectory (two tasks)
- Clinical Global Impression Scale
- Patient's Global Impression Scale
Who may be able to participate?
The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.
Inclusion Criteria:
- Vascular parkinsonism
- age 18 and older
Exclusion Criteria:
- pregnant or any, other medical, surgical, neurological or psychiatric conditions
- other restrictions which prevent you from undergoing TMS recording, such as; surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), and/ or heart/cardiac lines
- any past or current history of seizure disorder or epilepsy
- unable to give informed consent
Treatment, groups and participation
The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.
- Assignment
- Random assignment
- Masking
- Triple masked
Real rTMS Supplementary motor area
Real rTMS will be applied over the supplementary motor area
Device: Real rTMS Supplementary motor area
Sham rTMS Supplementary motor area
Sham rTMS will be applied over the supplementary motor area
Device: Sham rTMS Supplementary motor area
Real rTMS Supplementary motor area DEVICE
There will be a series of four rTMS blocks separated by 10 minutes. Each block will consist of 15 to 25 pulse trains of 1-second duration at 25 Hz, with an intertrain interval of 10 seconds.
Sham rTMS Supplementary motor area DEVICE
There will be no real brain stimulation in Sham rTMS, and participant will be blinded.
What researchers are measuring
Outcome measures describe what is being studied. They are not proof that a treatment works.
Primary measures
Unified Parkinson's Disease Rating Scale (UPDRS) part III-motor part (Number 18 ~31 of UPDRS)
Time frame: 2 days
Motor functions will be checked using UPDRS. Each item of the motor part ranges from 0 to 4 (0 means normal, 4 means worst condition). Total sum will be calculated.
Secondary measures
Finger tapping test with right hand
Time frame: 2 days
Finger tapping test with right hand, as quickly as possible for 15 second. The total number of taps will be calculated. The test will be twice with one minute interval. After the test performed twice, the average of the tests will be used.
The total number of steps during the stand-walk-sit (SWS) test
Time frame: 2 days
SWS test is Standing up, making a 9 m round trip, and sitting down as quickly as possible. The number of steps will be recorded.
The completion time during the SWS test
Time frame: 2 days
The completion time will be recorded.
Freezing episodes of gait trajectory
Time frame: 2 days
The number of freezing episodes during rapid full turns and dual task
Patient and Clinical Global Impression Scale
Time frame: 2 days
7-point scale that requires the patient (or clinician) to rate the response of the interventions. The rating will be numbered (1: very much improved; 2: much improved; 3: minimally improved; 4: no changes; 5: minimally worse; 6: much worse; 7: very much worse).
Review the complete result tables and limitations in the official record.
Open official results ↗Research locations (1)
The overall study status and a local site’s status can differ. Confirm that location’s availability before traveling.
1 locations
Inje university, Busan Paik HospitalBusan, South KoreaStatus unknown
Study team and timeline
- Lead sponsor
- Inje University
- Study start
- 2018-12 Estimated
- Primary completion
- 2024-12 Estimated
- Study completion
- 2025-12 Estimated
- First posted
- Oct 25, 2018 Actual
- Last updated
- Nov 10, 2026 Actual
Official study contacts
No central contact is listed. Check the locations and the official record.
Official study title
Effect of Repetitive Transcranial Magnetic Stimulation in Vascular Parkinsonism
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Source: ClinicalTrials.gov API v2. Information is submitted by sponsors and investigators. NLM does not approve the safety or science of all listed studies. Registry disclaimer.
Retrieved: Nov 12, 2026 · Last registry update: Nov 10, 2026