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Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV

Hiv · Cardiovascular Diseases

Older people with HIV (OPWH) are disproportionately impacted by cardiovascular disease (CVD) attributable to behavioral risk factors, and chronic HIV immune dysregulation resulting inflammation. Systemic inflammation is exacerbated by psychological d…

[Trial of device that is not approved or cleared by the U.S. FDA]

Evaluation of the Clinical Spectrum of Diabetes and Obesity in Youth and Adults

Obesity · Diabetes · Metabolic Disorders

Background: Diabetes and obesity are chronic diseases. They can affect blood flow and how the body processes nutrients, and complications over time can lead to early death. Diabetes can affect children as well as adults, but the disease seems to be m…

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

Non Small Cell Lung Cancer

This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan pl…

Prevention of Ischemic Stroke Recurrence Using Digital Technology Application

Ischemic Stroke · Digital Health

The goal of this study is to find out whether a comprehensive management program that uses a smart bracelet and a mobile app can help people who have had an ischemic stroke (a type of stroke caused by a blocked blood vessel in the brain) to prevent a…

Comparison Between Eccentric Hamstring Training and Sprint-Specific Training

Healthy Adult · Athlete · Exercise Training · Sport · Running · Ultrasound Imaging

The purpose of this study is to compare the effects of an intensity-, volume-, and time under tension-matched eccentric hamstring exercise intervention with the Romanian deadlift (RDL) and the Nordic hamstring exercise (NHE) to a sprint-specific trai…

Remote Monitoring and Virtual Collaborative Care For Hypertension Control to Prevent Cognitive Decline Phase II

Hypertension

This is a randomized, controlled, pragmatic trial designed as a "type I hybrid effectiveness-implementation trial" that tests a hypertension program integrating a virtual Collaborative Care Clinic (vCCC), home blood pressure monitoring, and telehealt…

Ambient AI Decision Support for Trauma Team Leaders in Simulated Resuscitations

Wounds and Injuries · Clinical Decision-Making · Decision Support Systems, Clinical

The goal of this study is to learn whether real-time decision support from an ambient artificial-intelligence (AI) coach improves how physicians lead simulated trauma resuscitations. The main question it aims to answer is: \- Do participants lead sim…

Patients' Attitudes Toward and Experiences With Buprenorphine Treatment

Opioid-use Disorder · Acceptability of Health Care · Opioid-Related Disorders

This study will disseminate five surveys collecting individual's attitudes and experiences during buprenorphine treatment for Opioid Use Disorder during the COVID-19 pandemic.

Evaluation of a Connected Interface to Improve the Quality of Life and the Disability of Patient With Rheumatic Diseases

Rheumatoid Arthritis

Musculoskeletal pathologies constitute a major public health problem. Rheumatologists, whether they practice in private or hospital settings, play a major role in the management of responsible for these ailments. Due to the increase in life expectanc…

Feasibility of Exercise and Transcranial Direct Current Stimulation for the Treatment of Post-traumatic Headache

Headaches Posttraumatic · Neck Pain

The goal of this prospective case series is to assess the feasibility of intervention and assessment protocols for telehealth intervention with mindfulness-based exercise, transcranial direct current stimulation, and their combination in Veterans wit…

An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study)

Major Depressive Disorder (MDD) · Major Depressive Disorder With Anxious Distress

This is an open-label, monotherapy, extension study to evaluate the safety and tolerability of SPT-300 (GlyphAllo) in adults with major depressive disorder (MDD), with or without anxious distress.