PNF Plus Progressive Rehabilitation for Adolescent Athletes With Osgood-Schlatter Syndrome
Osgood-Schlatter Disease
What this study involves
The registry does not currently label this study as recruiting. Ask about its status before planning a screening visit.
- Study type
- Interventional
- Phase
- Not applicable
- Age range
- 16 years - 18 years
- Sex eligible
- All sexes
- Healthy volunteers
- Not accepted
- Participants
- 12 Actual
These are starting points, not an eligibility decision. The research team must review the full requirements.
About the research
Osgood-Schlatter syndrome is a common cause of knee pain in adolescent athletes. It occurs during periods of growth and is often associated with sports activities involving running, jumping, and repeated knee movements. Pain may limit participation in sports and other physical activities.
This study aims to investigate whether combining proprioceptive neuromuscular facilitation (PNF) relaxation techniques with a progressive rehabilitation exercise programme is more effective than progressive rehabilitation exercises alone in reducing knee pain and improving knee range of motion in adolescent athletes with Osgood-Schlatter syndrome.
Twelve adolescent athletes with Osgood-Schlatter syndrome were allocated randomly into two groups. The first group received PNF hold-relax techniques targeting the quadriceps and hamstring muscles, together with a progressive rehabilitation exercise programme. The second group received the progressive rehabilitation exercise programme alone.
Both groups participated in rehabilitation sessions three times per week for 12 weeks. Knee pain and range of motion were assessed before the intervention, after 6 weeks, and after 12 weeks.
The study will compare changes in pain and knee mobility between the two groups to determine whether adding PNF relaxation techniques provides additional benefits to progressive rehabilitation exercises. The findings may help inform rehabilitation approaches for adolescent athletes with Osgood-Schlatter syndrome.
Read the full description
Osgood-Schlatter syndrome is an overuse-related condition affecting the tibial tubercle apophysis in adolescents, particularly those participating in sports involving repetitive running, jumping, and forceful quadriceps contraction. It commonly presents with anterior knee pain and tenderness around the tibial tubercle, which may interfere with sports participation and physical activity.
Conservative management generally includes activity modification and progressive rehabilitation exercises. However, additional approaches that may improve muscle flexibility, movement tolerance, and knee mobility warrant further investigation.
\*\*Study objective\*\*
The primary objective of this randomized controlled trial is to investigate the effects of combining proprioceptive neuromuscular facilitation (PNF) relaxation techniques with a progressive rehabilitation exercise programme on knee pain and range of motion in adolescent athletes with Osgood-Schlatter syndrome, compared with progressive rehabilitation exercises alone.
\*\*Study design and participants\*\*
This study uses a two-arm, parallel-group randomized controlled design involving 12 adolescent athletes with clinically diagnosed Osgood-Schlatter syndrome. Participants are allocated equally into two groups, with six participants in each group.
\*\*Intervention group: Combined PNF and progressive rehabilitation (CPRE)\*\*
Participants in the experimental group receive PNF hold-relax techniques targeting the quadriceps and hamstring muscle groups, in addition to a structured progressive rehabilitation exercise programme. The programme includes lower-limb strengthening exercises and exercises targeting the hip and core musculature.
\*\*Comparison group: Progressive rehabilitation exercises (RE)\*\*
Participants in the comparison group receive the structured progressive rehabilitation exercise programme without the additional PNF relaxation techniques.
\*\*Intervention duration and frequency\*\*
Both groups participate in rehabilitation sessions three times per week over a 12-week period. Each session lasts approximately 45-60 minutes.
\*\*Outcome assessments\*\*
Clinical assessments are performed at three time points: baseline, 6 weeks, and 12 weeks.
The principal outcomes include:
1. Knee pain: Pain intensity is assessed during the specified knee movements using a visual analogue scale (VAS).
2. Knee range of motion: Knee mobility is evaluated using goniometric measurements, including knee flexion and extension.
The study compares changes in these outcomes over time between the combined intervention group and the progressive rehabilitation group.
\*\*Data analysis\*\*
Changes in outcome measures are evaluated using a two-way mixed repeated-measures analysis of variance to examine the effects of group, time, and the group-by-time interaction. Statistical significance is evaluated using the prespecified significance level.
\*\*Potential significance\*\*
This study is intended to provide preliminary evidence regarding whether adding PNF hold-relax techniques to progressive rehabilitation exercises offers additional benefits for reducing knee pain and improving knee mobility in adolescent athletes with Osgood-Schlatter syndrome. The findings may contribute to the development of rehabilitation strategies for this population.
Who may be able to participate?
The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.
Inclusion Criteria:
Participants diagnosed with the condition investigated in the study. Participants meeting the specified age eligibility criteria. Participants able to participate in the prescribed rehabilitation exercise program.
Participants who provided informed consent.
Exclusion Criteria:
Participants with contraindications to the rehabilitation interventions. Participants with medical conditions that could interfere with participation or outcome assessment.
Participants who had received treatments that could influence the study outcomes, as specified in the study protocol.
Understand screeningTreatment, groups and participation
The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.
- Assignment
- Random assignment
- Masking
- Single masked
PNF + Rehabilitation Exercise Group
Participants received a combined intervention consisting of proprioceptive neuromuscular facilitation (PNF) techniques and a structured rehabilitation exercise program.
Behavioral: Proprioceptive Neuromuscular Facilitation (PNF) · Behavioral: Rehabilitation Exercise Program
Rehabilitation Exercise Group
Participants received a structured rehabilitation exercise program without the addition of proprioceptive neuromuscular facilitation (PNF) techniques.
Behavioral: Proprioceptive Neuromuscular Facilitation (PNF) · Behavioral: Rehabilitation Exercise Program
Proprioceptive Neuromuscular Facilitation (PNF) BEHAVIORAL
Proprioceptive neuromuscular facilitation (PNF) techniques were administered to participants in the experimental group in combination with the rehabilitation exercise program. PNF was used as an additional therapeutic component of the intervention.
Rehabilitation Exercise Program BEHAVIORAL
A structured rehabilitation exercise program administered to participants in both the experimental group (combined PNF and rehabilitation exercise group) and the active comparator group (rehabilitation exercise group alone).
What researchers are measuring
Outcome measures describe what is being studied. They are not proof that a treatment works.
Primary measures
Pain intensity measured using the Visual Analogue Scale (VAS)
Time frame: Baseline (T0), 6 weeks (T1), and 12 weeks (T2).
Pain intensity was assessed using the Visual Analogue Scale (VAS) to evaluate changes in pain severity following the intervention.
Secondary measures
Range of motion using a standard universal goniometer
Time frame: Baseline (T0), 6 weeks (T1), and 12 weeks (T2).
Range of motion was assessed using standard universal goniometer to evaluate changes in Range of motion following the intervention.
Review the complete result tables and limitations in the official record.
Open official results ↗Research locations (1)
The overall study status and a local site’s status can differ. Confirm that location’s availability before traveling.
1 locations
Mahmoud AL SayedBanhā, Qalyubia Governorate, EgyptStatus unknown
Study team and timeline
- Lead sponsor
- Benha University
- Study start
- Jul 1, 2026 Actual
- Primary completion
- Oct 5, 2026 Actual
- Study completion
- Oct 10, 2026 Actual
- First posted
- Nov 10, 2026 Actual
- Last updated
- Nov 10, 2026 Actual
Official study contacts
No central contact is listed. Check the locations and the official record.
Official study title
Effect of a Combined Proprioceptive Neuromuscular Facilitation and Progressive Rehabilitation Program on Knee Pain, Rang of Motion in Adolescent Athletes With Osgood-Schlatter Syndrome: a Randomized Controlled Trial
Ask Wellness Clinical Research
Your message goes to WCR, including when this study is run by another organization. WCR may offer general guidance but may not operate this trial, have access to its team or be able to enroll you.
Source: ClinicalTrials.gov API v2. Information is submitted by sponsors and investigators. NLM does not approve the safety or science of all listed studies. Registry disclaimer.
Retrieved: Nov 12, 2026 · Last registry update: Nov 10, 2026
