Comparison Between Different Insulin Resistance Markers and Their Correlation With Severity of Coronary Artery Disease in Non-diabetic Patients.
Ischemic Heart Disease (IHD)
What this study involves
The registry does not currently label this study as recruiting. Ask about its status before planning a screening visit.
- Study type
- Observational
- Phase
- Not applicable / not listed
- Age range
- 18 years - Not specified
- Sex eligible
- All sexes
- Healthy volunteers
- Not accepted
- Participants
- 60 Estimated
These are starting points, not an eligibility decision. The research team must review the full requirements.
About the research
This study aims to investigate the association between insulin resistance (IR) and coronary artery disease (CAD) in non-diabetic patients. Furthermore, it evaluates the predictive value of multiple insulin resistance indices - specifically, the homeostatic model assessment for insulin resistance (HOMA-IR), Metabolic score for insulin resistance (METS-IR), Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and triglyceride and glucose (TyG) index, as non-invasive markers of coronary artery disease severity. The diagnostic performance of these indices will be compared among patients with suspected CAD undergoing coronary angiography at the cardiac catheterization unit at Sohag University Hospital.
Who may be able to participate?
The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.
Inclusion Criteria:
- Aged ≥18 year.
- Both sexes
- Non-diabetic patients based on glycosylated hemoglobin (HbA1c) .
- Patient with Ischemic heart disease indicated for coronary angiography.
Exclusion Criteria:
- Patients age less than 18 years old.
- Insulin dependent diabetes
- Pregnant women
- End-stage renal disease on dialysis.
Study population
patients indicated for coronary angiography in sohag university hospital
Understand screeningTreatment, groups and participation
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- Assignment
- Not reported
- Masking
- Not reported
group 1 patients indicated for coronary angiography
Not reported in this registry record.
Diagnostic Test: This study aims to investigate the association between insulin resistance (IR) and coronary artery disease (CAD) in non-diabetic patients.
This study aims to investigate the association between insulin resistance (IR) and coronary artery disease (CAD) in non-diabetic patients. DIAGNOSTIC_TEST
evaluates the predictive value of multiple insulin resistance indices - specifically, the homeostatic model assessment for insulin resistance (HOMA-IR), Metabolic score for insulin resistance (METS-IR), Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and triglyceride and glucose (TyG) index, as non-invasive markers of coronary artery disease severity.
What researchers are measuring
Outcome measures describe what is being studied. They are not proof that a treatment works.
Primary measures
Association between Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)
Time frame: baseline, before coronary angiography, within the 2-hour assessment period.
Insulin resistance will be assessed using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), calculated as fasting plasma glucose and fasting insulin levels according to the following formula: HOMA-IR = \[FPG (mg/dL) x fasting insulin (microU/mL)\] / 405.
Results will be reported as a continuous, dimensionless index; higher values indicate greater insulin resistance.
The association between HOMA-IR and coronary artery disease severity will be evaluated using coronary angiographic findings, including SYNTAX score and TIMI flow grade.
Association between Metabolic Score for Insulin Resistance (METS-IR) and coronary artery disease severity.
Time frame: baseline, prior coronary angiography, within the 2-hour assessment period.
METS-IR will be calculated according to the following formula: Ln\[(2 × fasting plasma glucose (mg/dL)) + fasting triglycerides (mg/dL)\] × body mass index (kg/m²) ÷ Ln\[HDL-cholesterol (mg/dL)\]. Biochemical parameters will be derived from fasting venous blood collected before coronary angiography. Higher scores indicate greater insulin resistance.
The association between METS-IR and coronary artery disease severity will be evaluated using coronary angiographic findings, including SYNTAX score and TIMI flow grade.
Association between Triglyceride-Glucose (TyG) Index and coronary artery disease severity.
Time frame: baseline, prior coronary angiography, within the 2-hour assessment period.
The TyG index will be calculated according to the following formula: Ln\[fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL) ÷ 2\], using blood samples collected before coronary angiography. The index is dimensionless and serves as a surrogate marker of insulin resistance, with higher values indicating greater resistance.
The association between TyG index and coronary artery disease severity will be evaluated using coronary angiographic findings, including SYNTAX score and TIMI flow grade.
Association between Triglyceride to High-Density Lipoprotein Cholesterol Ratio (TG/HDL-C) and coronary artery disease severity.
Time frame: Within 2 hours before coronary angiography
The TG/HDL-C ratio will be calculated according to the following formula: fasting serum triglycerides (mg/dL) divided by fasting serum HDL-cholesterol (mg/dL), using blood samples collected before coronary angiography. The ratio is dimensionless and serves as a surrogate marker of insulin resistance, with higher values indicating greater resistance.
The association between TG/HDL-C ratio and coronary artery disease severity will be evaluated using coronary angiographic findings, including SYNTAX score and TIMI flow grade.
Assessment of coronary artery disease severity and anatomical complexity using SYNTAX score.
Time frame: During coronary angiography
The anatomical complexity and severity of coronary artery disease will be assessed using the SYNTAX score calculated from coronary angiographic images. The SYNTAX score will be calculated based on the number, location, and anatomical characteristics of coronary lesions with diameter stenosis of at least 50% in coronary vessels with a reference diameter of at least 1.5 mm. The total numerical score will be reported; higher scores indicate greater anatomical complexity. Categories are low (≤22), intermediate (23-32), and high (≥33).
The relationship between SYNTAX score and the four insulin resistance markers (HOMA-IR, METS-IR, TyG index, and TG/HDL-C ratio) will be evaluated.
Secondary measures
Assessment of coronary blood flow using TIMI flow grade.
Time frame: During coronary angiography
Coronary blood flow in all major coronary arteries will be assessed during coronary angiography using the Thrombolysis in Myocardial Infarction (TIMI) flow grading system. Coronary blood flow will be classified into four grades:
- TIMI Grade 0: No antegrade flow.
- TIMI Grade 1: Penetration without distal perfusion.
- TIMI Grade 2: Partial perfusion with delayed flow.
- TIMI Grade 3: Complete perfusion. The association between insulin resistance markers and TIMI flow grade will be evaluated
Review the complete result tables and limitations in the official record.
Open official results ↗Research locations (1)
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1 locations
Sohag University HospitalSohag, EgyptStatus unknown
Study team and timeline
- Lead sponsor
- Sohag University
- Study start
- Nov 1, 2026 Estimated
- Primary completion
- May 1, 2027 Estimated
- Study completion
- Aug 1, 2027 Estimated
- First posted
- Nov 10, 2026 Actual
- Last updated
- Nov 10, 2026 Actual
Official study contacts
Official study title
Comparison Between Different Insulin Resistance Markers and Their Correlation With Severity of Coronary Artery Disease in Non-diabetic Patients.
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Source: ClinicalTrials.gov API v2. Information is submitted by sponsors and investigators. NLM does not approve the safety or science of all listed studies. Registry disclaimer.
Retrieved: Nov 12, 2026 · Last registry update: Nov 10, 2026