Diagnostic Accuracy of Fine Needle Aspiration Cytology (FNAC) Compared to TI-RADS 3 in the Evaluation of Thyroid Nodules: A Prospective Study

What this study involves

The registry does not currently label this study as recruiting. Ask about its status before planning a screening visit.

Study type

Interventional

Phase

Not applicable

Age range

18 years - Not specified

Sex eligible

All sexes

Healthy volunteers

Not accepted

Participants

30 Estimated

These are starting points, not an eligibility decision. The research team must review the full requirements.

About the research

Thyroid nodules are common clinical findings, and accurate differentiation between benign and malignant nodules is essential for appropriate patient management. Ultrasonography is the primary imaging modality for thyroid nodule evaluation, while the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) provides a standardized approach for malignancy risk assessment.

Fine Needle Aspiration Cytology (FNAC) is an important diagnostic procedure for evaluating thyroid nodules, with cytological results classified according to the Bethesda System.

This prospective study aims to evaluate and compare the diagnostic accuracy of FNAC and ACR TI-RADS 3 classification in the assessment of thyroid nodules.

The study will include 30 adult patients with TI-RADS 3 thyroid nodules at Sohag University Hospital. All participants will undergo clinical examination, thyroid ultrasonography, TI-RADS classification, and ultrasound-guided FNAC. Cytological findings will be reported according to the Bethesda System. Histopathological examination of surgically excised thyroid specimens will be performed whenever available.

The diagnostic performance will be assessed using sensitivity, specificity, positive predictive value, and negative predictive value. Statistical analysis will be performed using SPSS.

Who may be able to participate?

The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.

Inclusion Criteria:

• Patients with thyroid nodules classified as ACR TI-RADS 3.
• Age ≥18 years.
• Patients who provide informed consent to participate in the study.

Exclusion Criteria:

• Age \<18 years.
• Previous history of thyroid cancer.
• Previous thyroid surgery.
• Incomplete evaluation.

Treatment, groups and participation

The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.

Assignment

Not applicable

Masking

No masking

What researchers are measuring

Outcome measures describe what is being studied. They are not proof that a treatment works.

Primary measures

Secondary measures

Research locations (1)

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1 locations

Study team and timeline

Lead sponsor

Sohag University

Study start

Apr 26, 2026 Actual

Primary completion

Apr 26, 2027 Estimated

Study completion

May 26, 2027 Estimated

First posted

Nov 10, 2026 Actual

Last updated

Nov 10, 2026 Actual

Official study contacts

No central contact is listed. Check the locations and the official record.