Targeted Minimally-Invasive Glaucoma Surgery

What this study involves

The registry does not currently label this study as recruiting. Ask about its status before planning a screening visit.

Study type

Interventional

Phase

Not applicable

Age range

45 years - Not specified

Sex eligible

All sexes

Healthy volunteers

Not accepted

Participants

37 Actual

These are starting points, not an eligibility decision. The research team must review the full requirements.

About the research

MIGS procedures are currently performed without targeting a specific region of the outflow pathway. The temporal surgical approach means that treatment is delivered to the nasal quadrant. Preclinical analyses have shown that targeted treatment of low-flow regions of the trabecular meshwork can improve efficacy. The aim of this study is to use aqueous angiography to guide the placement of an established MIGS procedure, excimer laser trabeculostomy (ELT; Elios Vision GmbH), in order to improve its efficacy.

Who may be able to participate?

The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.

Inclusion Criteria:

• age equal to or above 45 years
• written informed consent
• Cataract with indication for surgery
• preperimetric to moderate open-angle glaucoma
• central corneal thickness 480-620µm
• availability, willingness and ability to understand and give consent to study participation

Exclusion Criteria:

• participation in another interventional study
• previous glaucoma surgery
• previous selective laser trabeculoplasty
• ambiguous glaucoma diagnosis
• ocular hypertension
• corneal pathology with influence on intraocular pressure measurement
• inflammatory ocular disease
• increases risk for intraoperative floppy iris syndrome
• medical interventions planned in parallel, that interfere with the study intervention

Treatment, groups and participation

The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.

Assignment

Random assignment

Masking

No masking

What researchers are measuring

Outcome measures describe what is being studied. They are not proof that a treatment works.

Primary measures

Research locations (1)

The overall study status and a local site’s status can differ. Confirm that location’s availability before traveling.

1 locations

Study team and timeline

Lead sponsor

Johannes Kepler University of Linz

Study start

Oct 3, 2024 Actual

Primary completion

Jul 10, 2026 Actual

Study completion

Jul 10, 2026 Actual

First posted

Nov 10, 2026 Actual

Last updated

Nov 10, 2026 Actual

Official study contacts

No central contact is listed. Check the locations and the official record.