Nurse-Led Interventions Addressing Physical Exercise and Psychological Needs on Enhancing Outcomes in Patients With Chronic Renal Failure
Nurse-Led Interventions · Physical Exercise · Psychological Needs · Enhance · Chronic Renal Failure
What this study involves
The registry says this study is recruiting. Individual locations may have different availability.
- Study type
- Interventional
- Phase
- Not applicable
- Age range
- 18 years - 60 years
- Sex eligible
- All sexes
- Healthy volunteers
- Not accepted
- Participants
- 110 Estimated
These are starting points, not an eligibility decision. The research team must review the full requirements.
About the research
This study aimed to evaluate the effect of a nurse-led intervention addressing physical exercise and psychological needs on enhancing outcomes among patients with chronic renal failure.
Read the full description
Chronic kidney disease (CKD) previously referred to as chronic renal failure (CRF), one of the leading health issues throughout the world, it is one of the very few non-communicable diseases leading to death.
Beyond physical symptoms, chronic renal failure imposes a considerable psychological burden. The lifelong nature of the disease, strict dietary and fluid restrictions, dependence on dialysis, uncertainty regarding prognosis, financial stress, and disruption of family and occupational roles predispose patients to anxiety, depression, emotional distress, and poor self-esteem.
Regular physical activity is widely recognized as an essential non-pharmacological strategy for improving health outcomes in patients with CKD. Research has demonstrated that individualized exercise programs, including aerobic, resistance, and flexibility training, can enhance cardiovascular endurance, increase muscle strength, improve functional performance, alleviate fatigue, and promote better health-related quality of life.
Nurses play a central role in the multidisciplinary management of patients with CKD by providing continuous, patient-centered care throughout the disease management. Nurse-led interventions involve a broad range of activities, including health education, promotion of physical activity, symptom assessment and monitoring, psychosocial support, behavioral counseling, self-management education, and coordination of care among healthcare professionals.
Who may be able to participate?
The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.
Inclusion Criteria:
- Patients aged from 18 to 60 years.
- Both sexes.
- Diagnosed with chronic renal failure, patients undergoing regular hemodialysis or admitted to the internal medicine department during the data collection period.
- Patients who are conscious and able to communicate effectively, and patients willing to participate voluntarily in the study.
Exclusion Criteria:
- Patients with severe physical immobility, or medical conditions that completely contraindicate low-to-moderate physical exercise.
- Patients with cognitive impairment or pre-existing severe psychiatric disorders prior to CRF diagnosis.
Treatment, groups and participation
The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.
- Assignment
- Not randomized
- Masking
- No masking
Control Group Protocol
Patients were received routine conventional hospital care and standard department instructions. This includes standard medical management, routine nursing check-ins, and any pre-existing educational brochures standard to the ward.
Procedure: Conventional hospital care
Study Group Protocol (Nurse-Led Intervention)
Patients were received a dual-component intervention, meticulously scheduled to align with their clinical status.
Procedure: Dual-component intervention
Conventional hospital care PROCEDURE
Patients were received routine conventional hospital care and standard department instructions. This includes standard medical management, routine nursing check-ins, and any pre-existing educational brochures standard to the ward.
Dual-component intervention PROCEDURE
Patients were received a dual-component intervention, meticulously scheduled to align with their clinical status.
What researchers are measuring
Outcome measures describe what is being studied. They are not proof that a treatment works.
Primary measures
Change in Fatigue Level
Time frame: 3 months after intervention completion
Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale, which consists of 13 items with a total score ranging from 0 to 52. Higher scores indicate less fatigue and better functional well-being.
Secondary measures
Change in Anxiety Level
Time frame: 3 months after intervention completion
Anxiety was assessed using the Hospital Anxiety and Depression Scale (HADS), anxiety subscale. Scores range from 0 to 21, with higher scores indicating greater anxiety.
Change in Depression Level
Time frame: 3 months after intervention completion
Depression was assessed using the Hospital Anxiety and Depression Scale (HADS), depression subscale. Scores range from 0 to 21, with higher scores indicating greater depressive symptoms.
Change in Health-Related Quality of Life
Time frame: 3 months after intervention completion
Health-related quality of life was assessed using the quality-of-life questionnaire which comprises 36 items grouped into five domains: Physical Component Summary (PCS)- general physical health, Mental Component Summary (MCS) - emotional and psychological well-being, Burden of Kidney Disease (4 items), Symptoms/Problems of Kidney Disease (12 items), Effects of Kidney Disease on Daily Life (8 items). Scoring: Each domain score is transformed to a 0-100 scale.
Change in Functional Exercise Capacity
Time frame: 3 months after intervention completion
Functional exercise capacity was assessed using the Six-Minute Walk Test (6MWT). The distance covered during six minutes was recorded in meters. An increase in the distance walked indicates improvement in functional exercise capacity.
Review the complete result tables and limitations in the official record.
Open official results ↗Research locations (1)
The overall study status and a local site’s status can differ. Confirm that location’s availability before traveling.
1 locations
Menoufia UniversityShibīn al Kawm, Menoufia, EgyptRecruiting
Study team and timeline
- Lead sponsor
- Menoufia University
- Study start
- Feb 1, 2026 Actual
- Primary completion
- Jul 1, 2027 Estimated
- Study completion
- Jul 1, 2027 Estimated
- First posted
- Nov 10, 2026 Actual
- Last updated
- Nov 10, 2026 Actual
Official study contacts
Official study title
Effect of Nurse-Led Interventions Addressing Physical Exercise and Psychological Needs on Enhancing Outcomes in Patients With Chronic Renal Failure
Ask Wellness Clinical Research
Your message goes to WCR, including when this study is run by another organization. WCR may offer general guidance but may not operate this trial, have access to its team or be able to enroll you.
Source: ClinicalTrials.gov API v2. Information is submitted by sponsors and investigators. NLM does not approve the safety or science of all listed studies. Registry disclaimer.
Retrieved: Nov 12, 2026 · Last registry update: Nov 10, 2026