Fulvic Acid Supplementation and Metabolic Syndrome

THE QUICK READ

What this study involves

The registry says this study is recruiting. Individual locations may have different availability.

Study type: Interventional
Phase: Not applicable
Age range: 18 years - 65 years
Sex eligible: All sexes
Healthy volunteers: Not accepted
Participants: 60 Estimated

These are starting points, not an eligibility decision. The research team must review the full requirements.

About the research

Fulvic acid is a naturally occurring compound derived from the decomposition of organic matter in soil over long periods. Fulvic acid complexes, such as MLG-50 (MLG-50® Mineral Logic, Kalamazoo, Michigan), offer a highly concentrated, water-soluble form of fulvic acid that contains over 70 trace minerals and elements. Our preclinical studies have found that a soil derived organic mineral complex rich in fulvic acid prevented the high fat diet induced hyperglycemia, endothelial dysfunction, liver injury, endotoxemia, and gut dysbiosis induced by high-fat feeding in rats. We propose to examine the efficacy of fulvic acid (both 50 mg and 100 mg daily for 12 weeks) in the mitigation of symptoms related to metabolic syndrome.

Read the full description

Clinical trials examining the efficacy of fulvic acid on health parameters are scarce. However, shilajit, a natural substance rich in fulvic acid, was shown to reduce triglycerides, cholesterol, and increase HDL cholesterol as well as antioxidant status in healthy college students (n=30) after 45 days of supplementation (2 g daily). However, this quasi-experimental trial did not randomize participants into experimental groups, and causality cannot be evaluated. A 2018 review of the peer-reviewed literature on the therapeutic potential of fulvic acid concluded that although the available research is minimal, there was 'substantial evidence' to pursue fulvic acid research for improving biomarkers linked to chronic inflammatory diseases.

Who may be able to participate?

The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.

Inclusion Criteria:

metabolic syndrome or prediabetes

Exclusion Criteria:

pregnant or nursing
multiple medications to treat obesity, heart disease, thyroid conditions, cancer
smokers
competing athletes
vegetarians

Understand screening

Treatment, groups and participation

The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.

Assignment: Random assignment
Masking: Double masked

Fulvic acid 50

50 mg

Dietary Supplement: fulvic acid

Fulvic acid 100

100 mg

Dietary Supplement: fulvic acid

Placebo

cornstarch

Other: Placebo

fulvic acid DIETARY_SUPPLEMENT

50 mg

fulvic acid DIETARY_SUPPLEMENT

100 mg

Placebo OTHER

cornstarch

Prepare your questions