RecruitingNCT07781605ClinicalTrials.gov record

Ambient Temperature and Thermoregulation During Exercise in Children and Youth

Body Temperature Changes · Heat Stress · Child Development · Heat · Physiological Stress

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THE QUICK READ

What this study involves

The registry says this study is recruiting. Individual locations may have different availability.

Study type: Interventional
Phase: Not applicable
Age range: 9 years - 25 years
Sex eligible: All sexes
Healthy volunteers: Accepted
Participants: 12 Estimated

These are starting points, not an eligibility decision. The research team must review the full requirements.

About the research

Little is known about how children and youth regulate body temperature during exercise across different environmental temperatures compared with young adults, including whether differences in whole-body heat exchange contribute to their responses. The goal of this clinical trial is to determine how ambient temperature affects thermoregulation during exercise in boys and girls aged 9-16 years compared with young adult men and women aged 20-25 years. Participants will complete four study visits at ambient temperatures of 22°C (Celsius; 72°F, Fahrenheit), 26°C (79°F), 31°C (88°F), and 36°C (97°F), while exercising at the same moderate-intensity metabolic heat production of 160 W/m² (W = watts, m = meters). During each visit, participants will complete four 15-minute periods of exercise (exercise bouts 1, 2, 3 and 4 respectively) separated by 15-minute rest periods. Testing will be performed in a whole-body air calorimeter, a specialized chamber that precisely measures heat lost through evaporation and dry heat exchange and the amount of heat stored in the body. These measurements, together with core temperature and heart rate, will allow researchers to determine how increasing ambient temperature affects the body's ability to lose heat and whether these responses differ between children and youth and young adults.

Who may be able to participate?

The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.

Inclusion Criteria:

Healthy male or female.
Aged 9-16 years or 20-25 years.
Habitually active, defined as participating in regular physical activity at least 3 times per week for at least 20 minutes per session over the previous 6 months.
Able to understand and communicate in English or French.
For participants younger than 18 years, written parental or guardian consent and participant assent are required.

Exclusion Criteria:

Acute illness at the time of testing (e.g., cold, flu, or infection).
History of a chronic medical condition that may affect thermoregulation, cardiovascular function, or exercise capacity (e.g., cardiovascular disease, metabolic disorders, respiratory disease including asthma requiring regular medication, or neurological disorders).
Use of medications known to affect thermoregulation, hydration status, or cardiovascular responses.
History of heat-related illness (e.g., heat exhaustion or heat stroke).
Digestive abnormalities or gastrointestinal conditions that may contraindicate ingestion of a telemetry pill.
Any condition that, in the opinion of the investigators, would compromise participant safety or the integrity of the data.

Understand screening

Treatment, groups and participation

The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.

Assignment: Random assignment
Masking: No masking

Exercise at 22°C

Participants will complete intermittent moderate-intensity exercise at an ambient temperature of 22°C (celsius; 72°F, fahrenheit). Exercise will be performed at a metabolic heat production of 160 W/m² (W = watts, m = meters) and will consist of four 15-minute exercise periods separated by 15-minute rest periods. Exercise workload will be individually adjusted to achieve the prescribed metabolic heat production.

Other: Exercise at 22°C

Exercise at 26°C

Participants will complete intermittent moderate-intensity exercise at an ambient temperature of 26°C (79°F). Exercise will be performed at a metabolic heat production of 160 W/m² and will consist of four 15-minute exercise periods separated by 15-minute rest periods. Exercise workload will be individually adjusted to achieve the prescribed metabolic heat production.

Other: Exercise at 26°C

Exercise at 31°C

Participants will complete intermittent moderate-intensity exercise at an ambient temperature of 31°C (88°F). Exercise will be performed at a metabolic heat production of 160 W/m² and will consist of four 15-minute exercise periods separated by 15-minute rest periods. Exercise workload will be individually adjusted to achieve the prescribed metabolic heat production.

Other: Exercise at 31°C

Exercise at 36°C

Participants will complete intermittent moderate-intensity exercise at an ambient temperature of 36°C (97°F). Exercise will be performed at a metabolic heat production of 160 W/m² and will consist of four 15-minute exercise periods separated by 15-minute rest periods. Exercise workload will be individually adjusted to achieve the prescribed metabolic heat production.

Other: Exercise at 36°C

Exercise at 22°C OTHER

Participants complete intermittent exercise at a metabolic heat production of 160 W/m² in an ambient temperature of 22°C (72°F).

Exercise at 26°C OTHER

Participants complete intermittent exercise at a metabolic heat production of 160 W/m² in an ambient temperature of 26°C (79°F).

Exercise at 31°C OTHER

Participants complete intermittent exercise at a metabolic heat production of 160 W/m² in an ambient temperature of 31°C (88°F).

Exercise at 36°C OTHER

Participants complete intermittent exercise at a metabolic heat production of 160 W/m² in an ambient temperature of 36°C (97°F).

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