Stepwise PEEP vs Sustained Inflation in Bariatric Surgery Patients
Recruitment · Bariatric Surgery Candidate
What this study involves
The registry does not currently label this study as recruiting. Ask about its status before planning a screening visit.
- Study type
- Interventional
- Phase
- Not applicable
- Age range
- 18 years - Not specified
- Sex eligible
- All sexes
- Healthy volunteers
- Not accepted
- Participants
- 102 Actual
These are starting points, not an eligibility decision. The research team must review the full requirements.
About the research
Male and female patients Undergoing laparoscopic bariatric surgeries will be subjected for lung recruitment at end of surgery before emergence from anesthesia by two different methods . to evaluate which might be safer and more effective
Read the full description
In the SI group:, the anesthesiologist adjust the ventilator to manual ventilation mode and ad¬just The ventilator will be switched to manual mode, and the airway pressure-limiting valve will be set to 30 cmH₂O. A sustained manual inflation was then applied by gradually squeezing the anesthesia reservoir bag over 3-5 seconds until a peak airway pressure (Ppeak) of 30 cmH₂O was achieved. This pressure was maintained continuously for 30 seconds. Following the maneuver, mechanical ventilation was resumed with positive end-expiratory pressure (PEEP) back to 5 cmho In the IP group:, alveolar recruitment will be performed as follows: ventilation will be set to pressure control mode and the driving pressure maintained at 10 cmH2O with an initial PEEP of 5 cmH2O, respiratory rate 8-10, I:E 1-1PEEP will be then increased by 5 cmH2O ev¬ery 30 s until the Ppeak reached 30 cmH2O (so peep will reach 20), held for 30 s , then PEEP will be gradually reduced at intervals of 5 cmH2O down to 5 cmH2O, when initial volume control ventilation will be resumed. In the incremental PEEP group, PEEP was increased stepwise by 5 cmH₂O every 3-5 breaths until a peak airway pressure of 30 cmH₂O was achieved, after which mechanical ventilation was resumed with maintenance PEEP. The total duration of the recruitment maneuver was approximately 60-90 seconds.
Who may be able to participate?
The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.
Inclusion Criteria:
1. Anesthesiologists (ASA) physical status II, of either sex Age ≥18 y.
2. Undergoing laparoscopic bariatric surgeries; sleeve gastrectomy, mini gastric bypass
3. BMI (35-60)
Exclusion Criteria:
1. Pre-existing severe pulmonary disease
2. Baseline hypoxemia SpO₂ \<92% on room air
3. History of barotrauma
4. Previous pneumothorax
5. Known pulmonary bullae or emphysematous blebs
Treatment, groups and participation
The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.
- Assignment
- Random assignment
- Masking
- Double masked
group SI
receive 30 cmH₂O sustained inflation for 30seconds
Procedure: sustained inflation recruitement
group IP
receive PEEP was increased stepwise by 5 cmH₂O every 5 breaths until a peak airway pressure of 30 cmH₂O
Procedure: Stepwise PEEP
sustained inflation recruitement PROCEDURE
anesthesiologist adjust the ventilator to manual ventilation mode and ad¬just The ventilator was switched to manual mode, and the airway pressure-limiting valve was set to 30 cmH₂O. A sustained manual inflation was then applied by gradually squeezing the anesthesia reservoir bag over 3-5 seconds until a peak airway pressure (Ppeak) of 30 cmH₂O
Stepwise PEEP PROCEDURE
: ventilation will be set to pressure control mode and the driving pressure maintained at 10 cmH2O with an initial PEEP of 5 cmH2O, respiratory rate 8-10, I:E 1-1PEEP will be then increased by 5 cmH2O ev¬ery 30 s until the Ppeak reached 30 cmH2O
What researchers are measuring
Outcome measures describe what is being studied. They are not proof that a treatment works.
Primary measures
Postoperative lung aeration
Time frame: Postoperative upon admission to the post-anesthesia care unit approximately within first 15 minutes after extubation
lung ultrasound scoring system
Secondary measures
Postoperative oxygenation
Time frame: Postoperative upon admission to the post-anesthesia care unit Approximately within first 15 minutes after extubation and repeated before discharge
SpO₂
Oxygen requirement in PACU
Time frame: in the post-anesthesia care unit 15 minutes after extubation
to maintain SpO₂ ≥94%.
Significant desaturation during the maneauver
Time frame: from beginning till end of the recruitment maneauver
Intraprocedural significant desaturation was defined as SPO2 \< 90% or a decrease of more than 5% from the pre-maneuver baseline.
Postrecruitement hypotension
Time frame: postprocedural; Immediately after the end maneauver
a systolic blood pressure \< 80 mmHg, diastolic blood pressure \< 50 mmHg, or a reduction in mean blood pressure \> 20% from baseline.
Review the complete result tables and limitations in the official record.
Open official results ↗Research locations (1)
The overall study status and a local site’s status can differ. Confirm that location’s availability before traveling.
1 locations
Ain Shams university hospitalsCairo, EgyptStatus unknown
Study team and timeline
- Lead sponsor
- Ain Shams University
- Study start
- Apr 19, 2026 Actual
- Primary completion
- Oct 24, 2026 Actual
- Study completion
- Nov 4, 2026 Actual
- First posted
- Apr 13, 2026 Actual
- Last updated
- Nov 10, 2026 Actual
Official study contacts
No central contact is listed. Check the locations and the official record.
Official study title
Comparison of Stepwise PEEP vs Sustained Inflation Recruitment Maneuvers on Postoperative Oxygenation and Atelectasis in Bariatric Surgery Patients
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Source: ClinicalTrials.gov API v2. Information is submitted by sponsors and investigators. NLM does not approve the safety or science of all listed studies. Registry disclaimer.
Retrieved: Nov 12, 2026 · Last registry update: Nov 10, 2026