Clinical-randomized Study of the Influence of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on Muscular Fitness and Regeneration After Elective Total Knee Arthroplasty
Osteoarthritis (OA) of the Knee · Muscle Atrophy
What this study involves
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- Study type
- Interventional
- Phase
- Not applicable
- Age range
- 18 years - Not specified
- Sex eligible
- All sexes
- Healthy volunteers
- Not accepted
- Participants
- 25 Actual
These are starting points, not an eligibility decision. The research team must review the full requirements.
About the research
The present study investigates the effects of blood flow restriction training on muscular recovery during out-patient rehabilitation after elective total knee arthroplasty
Read the full description
The present study evaluated the impact of blood flow restriction training in the context of three-week outpatient rehabilitation following TKA, in accordance with the guidelines of the German Pension Insurance System. The in-rehabilitation and post-rehabilitation muscle status, strength, knee functionality, impairments in daily life and subjective pain perception were measured.
Who may be able to participate?
The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.
Inclusion Criteria:
- Physical Fitness for Rehabilitation
- Primary TKA surgery
- BMI \< 35
Exclusion Criteria:
- Sickle Cell Anemia
- Vascular Intervention on the lower extremities
- Open Wounds
Treatment, groups and participation
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- Assignment
- Random assignment
- Masking
- Double masked
Control Group
Control sham condition which performed the exercise with a fixed pressure of 20mmHg
Procedure: Sham-BFR
Blood Flow Restriction Group
This intervention groups performed training on the operated limb with a BFR pressure corresponding to 60% of the individual limb occlusion pressure
Procedure: Blood Flow Restriction Training
Sham-BFR PROCEDURE
The exercise protocol for the operated leg (with sham pressure of 20mmHg) consisted of four sets with 75 repetitions (reps) in total (1. Set: 30 reps, 2.-4. Set: 15 reps) with 30% of the individual one-repetition maximum for each exercise and were performed five times per week during the three-week outpatient rehabilitation.
Blood Flow Restriction Training PROCEDURE
The exercise protocol for the operated leg (with a BFR pressure of 60% of the LOP) consisted of four sets with 75 repetitions (reps) in total (1. Set: 30 reps, 2.-4. Set: 15 reps) with 30% of the individual one-repetition maximum for each exercise and were performed five times per week during the three-week outpatient rehabilitation.
What researchers are measuring
Outcome measures describe what is being studied. They are not proof that a treatment works.
Primary measures
Postoperative Pain
Time frame: Pre- to 6 weeks Post Rehabilitation
Postoperative Pain was assessed by KOOS and SF-36
Muscle Strength
Time frame: Pre- to 6 weeks Post Rehabilitation
Isometric muscle strength was measured on a DDRobotec (Dynamic Devices AG, Zurich, Switzerland), a pneumatic, computer-controlled leg press
Review the complete result tables and limitations in the official record.
Open official results ↗Research locations (1)
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1 locations
University Hospital BonnBonn, North Rhine-Westphalia, GermanyStatus unknown
Study team and timeline
- Lead sponsor
- University Hospital, Bonn
- Study start
- Jun 1, 2023 Actual
- Primary completion
- Dec 31, 2024 Actual
- Study completion
- Jan 1, 2025 Actual
- First posted
- Apr 24, 2025 Actual
- Last updated
- Nov 10, 2026 Actual
Official study contacts
No central contact is listed. Check the locations and the official record.
Official study title
Clinical-randomized Study of the Influence of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on Muscular Fitness and Regeneration After Elective Total Knee Arthroplasty
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Source: ClinicalTrials.gov API v2. Information is submitted by sponsors and investigators. NLM does not approve the safety or science of all listed studies. Registry disclaimer.
Retrieved: Nov 12, 2026 · Last registry update: Nov 10, 2026