Establishment of Biobank of Nasal Epithelium Samples From Healthy Volunteers
Healthy
What this study involves
The registry does not currently label this study as recruiting. Ask about its status before planning a screening visit.
- Study type
- Observational
- Phase
- Not applicable / not listed
- Age range
- 18 years - 99 years
- Sex eligible
- All sexes
- Healthy volunteers
- Accepted
- Participants
- 120 Estimated
These are starting points, not an eligibility decision. The research team must review the full requirements.
About the research
Background:
Infections in the lower respiratory tract (lungs) are the leading cause of death from infectious disease worldwide. This was true even before the COVID-19 pandemic. Respiratory viruses are still a major health threat. Many of these viruses infect people by penetrating the thin skin that lines the nose. These viruses can also spread easily to other people when they multiply in the tissues that line the nose. Researchers want to learn more about what these viruses do inside the nose, how they get from the nose to the lungs, and how they spread from person to person.
Objective:
To collect cell samples from inside the noses of healthy people. These cells will be stored for use in future research on respiratory diseases.
Eligibility:
Healthy volunteers aged 18 years and older.
Design:
Most participants will have 1 visit on 1 day. They will be asked questions. Those who have a runny nose, coughing, congestion, or fever will be asked to wait up to 21 days before participating.
Participants will be given a slender swab with small bristles at the end. They will rub the inside of their nose with the swab. A clinic staff member will be present to help, if needed.
Participants will provide their name, age, and sex. This information will be encoded so that only certain researchers will know the participants identities.
Participants will not be contacted again....
Read the full description
Study Description:
This is a repository protocol with prospective sample collection to provide samples needed for future studies of the pathogenesis of emerging respiratory viruses. Nasal brushings will be collected from approximately 100 healthy volunteers at RML and stored in the LV to be made available for future research studies that will be conducted under separate protocols, as applicable.
Primary Objective:
To obtain nasal epithelium brushes from healthy volunteers for 1) establishment of upper respiratory tract organoids, 2) assay validation, and 3) use for research into the pathogenesis of emerging respiratory viruses.
Who may be able to participate?
The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.
- INCLUSION CRITERIA:
In order to be eligible to participate in this study, an individual must meet all of the following criteria:
- Aged \>=18 years.
- Able to provide informed consent.
- Willing to allow biological samples and data to be stored for future research.
EXCLUSION CRITERIA:
An individual who meets any of the following criteria will be excluded from participation in this
study:
- History of respiratory symptoms including but not limited to runny nose, coughing, congestion, and/or fever within the past 14 days.
- NIH and laboratory staff with direct involvement in the operation or maintenance of the repository are excluded from participation.
- An individual who has any condition that, in the judgment of the investigator, may put them at undue risk or make them unsuitable for participation in the study will be excluded.
Study population
Healthy volunteers, aged 18 years and older, may be recruited from the general public, people working at and/or visiting Rocky Mountain Laboratories (RML), and NIH staff members and their family/contacts.
Understand screeningTreatment, groups and participation
The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.
- Assignment
- Not reported
- Masking
- Not reported
Healthy Volunteers
Healthy volunteers aged 18 years and older
What researchers are measuring
Outcome measures describe what is being studied. They are not proof that a treatment works.
Primary measures
To obtain nasal epithelium brushes from healthy volunteers for 1) establishment of upper respiratory tract organoids, 2) assay validation, and 3) use for research into the pathogenesis of emerging respiratory viruses.
Time frame: 10 years
To obtain nasal epithelium brushes from healthy volunteers for 1) establishment of upper respiratory tract organoids, 2) assay validation, and 3) use for research into the pathogenesis of emerging respiratory viruses.
Review the complete result tables and limitations in the official record.
Open official results ↗Research locations (1)
The overall study status and a local site’s status can differ. Confirm that location’s availability before traveling.
1 locations
Rocky Mountain LaboratoriesHamilton, Montana, United StatesStatus unknown
Study team and timeline
- Lead sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
- Study start
- Nov 15, 2026 Estimated
- Primary completion
- Oct 31, 2033 Estimated
- Study completion
- Oct 31, 2033 Estimated
- First posted
- Nov 7, 2023 Actual
- Last updated
- Nov 10, 2026 Actual
Official study contacts
Official study title
Establishment of a Biobank of Nasal Epithelium Samples From Healthy Volunteers
Ask Wellness Clinical Research
Your message goes to WCR, including when this study is run by another organization. WCR may offer general guidance but may not operate this trial, have access to its team or be able to enroll you.
Source: ClinicalTrials.gov API v2. Information is submitted by sponsors and investigators. NLM does not approve the safety or science of all listed studies. Registry disclaimer.
Retrieved: Nov 12, 2026 · Last registry update: Nov 10, 2026