CompletedNCT04788628ClinicalTrials.gov record

Auditory Stimulation Effects on Sleep and Memory in Patients With Epilepsy

Epilepsy

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THE QUICK READ

What this study involves

The registry does not currently label this study as recruiting. Ask about its status before planning a screening visit.

Study type: Interventional
Phase: Not applicable
Age range: 12 years - 65 years
Sex eligible: All sexes
Healthy volunteers: Not accepted
Participants: 24 Actual

These are starting points, not an eligibility decision. The research team must review the full requirements.

About the research

This study will investigate the role of coordinated brain rhythms during sleep in memory consolidation and determine whether playing precisely timed brief bursts of noise can enhance these rhythms and improve memory in epilepsy inpatients with implanted hippocampal electrodes.

Read the full description

The investigators will test the hypotheses that coordinated brain rhythms during nonrapid eye movement sleep are associated with memory consolidation and can be enhanced with auditory stimulation (playing precisely timed brief bursts of quiet noise) to improve memory. The investigators will measure differences in sleep and memory performance in epilepsy inpatients with implanted hippocampal electrodes and continuous full scalp EEG monitoring under three overnight sleep conditions: a baseline night; a memory night during which sleep-dependent memory consolidation is assessed with the finger tapping motor sequence task (MST) with training prior to sleep and testing the next morning; and a stimulation night during which participants train on the MST, have precisely timed auditory stimulation during the sleep that follows, and are tested on the MST in the morning.

Who may be able to participate?

The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.

Inclusion Criteria:

Inpatients with epilepsy
Aged 12-65
Undergoing clinically indicated continuous scalp and intracranial EEG monitoring with implanted hippocampal electrodes
Fluent in English
Able to give informed consent/assent (for minors aged 12-17 or adults with an appointed guardian)

Exclusion Criteria:

Intellectual disability impairing ability to perform task
Motor problems that preclude finger tapping task
Previous surgery anticipated to disrupt coordination of sleep oscillations in the circuitry of interest

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Treatment, groups and participation

The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.

Assignment: Not applicable
Masking: No masking

Epilepsy inpatients

Epilepsy inpatients with implanted hippocampal electrodes and continuous scalp EEG monitoring

Other: Baseline · Other: Motor procedural memory task · Other: Motor procedural memory task plus auditory stimulation

Baseline OTHER

Hippocampal and scalp EEG monitoring during overnight sleep

Motor procedural memory task OTHER

Training on the finger tapping MST prior to monitored overnight sleep with MST testing the following morning

Motor procedural memory task plus auditory stimulation OTHER

Training on the finger tapping MST prior to monitored overnight sleep that includes auditory stimulation, with MST testing the following morning

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