Managed Access Program for Combination Treatment With Belantamab Mafodotin in Multiple Myeloma

What this study involves

The registry does not currently label this study as recruiting. Ask about its status before planning a screening visit.

Study type

Expanded access

Phase

Not applicable / not listed

Age range

18 years - Not specified

Sex eligible

All sexes

Healthy volunteers

Not reported

Participants

Not reported

These are starting points, not an eligibility decision. The research team must review the full requirements.

About the research

Compassionate use access to belantamab mafodotin (GSK2857916) (in combination with bortezomib/dexamethasone or pomalidomide/dexamethasone) for eligible participants with multiple myeloma previously treated with at least 1 prior line of therapy.

Who may be able to participate?

The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.

Specific eligibility criteria must be met, these include:

1. There is no satisfactory alternative treatment for the patient including approved standard of care treatments for their multiple myeloma; and
2. There is reason to believe that the benefit to the patient using belantamab mafodotin outweighs the risk
3. Patient does not qualify for, or is unable to participate in, other ongoing clinical trials

INCLUSION CRITERIA:

1. Written informed consent
2. Diagnosis of multiple myeloma and/or plasma cell dyscrasias and either:

1. For combination with bortezomib/dexamethasone; previously treated with at least 1 prior line of MM therapy and must have documented disease progression during or after their most recent therapy OR
2. For combination with pomalidomide/dexamethasone; have been previously treated with at least 1 prior line of MM therapy including a lenalidomide-containing regimen (lenalidomide must have been administered for at least 2 consecutive cycles) and must have documented disease progression during or after their most recent therapy.
3. Able to obtain ophthalmic examinations at baseline, before the next 3 subsequent treatment cycles and as clinically indicated on treatment
4. Contraception requirements

A. Female Participants: A female patient is eligible to participate if one of the following conditions applies:

I. The patient Is not a woman of childbearing potential (WOCBP) OR II. The patient Is a WOCBP and using an effective contraceptive method during treatment with belantamab mafodotin and for 4 months after the last dose. The patient must also have a negative highly sensitive serum pregnancy test within 72 hours of dosing on Cycle 1 Day 1. Please discuss with GSK physician if the patient is pregnant, breast-feeding or planning to have a baby.

B. Male participants with female partners of child-bearing potential are eligible to participate if they agree to use effective contraception during treatment with belantamab mafodotin until 6 months after the last dose

EXCLUSION CRITERIA:

1. If considering combination with bortezomib/dexamethasone intolerant or refractory to bortezomib. If considering combination with pomalidomide/dexamethasone intolerant or refractory to pomalidomide
2. Alanine transaminase (ALT) \>2.5x upper limit of normal (ULN).
3. Total bilirubin \>1.5xULN; patients with Gilbert's syndrome can be included with total bilirubin \>1.5xULN as long as direct bilirubin is ≤1.5xULN.
4. Cirrhosis or current unstable liver or biliary disease per physician assessment defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminaemia, esophageal or gastric varices, persistent jaundice.
5. Patients with Hepatitis B will be excluded unless:

1. HbcAb positive, HBsAg negative: HBV deoxyribonucleic acid (DNA) undetectable and Antiviral treatment instituted if HBV DNA becomes detectable
2. HBsAg positive at screen or within 3 months prior to first dose: HBV DNA undetectable and Antiviral treatment maintained throughout program treatment
6. Patients with positive hepatitis C antibody test result or positive hepatitis C ribonucleic acid (RNA) test result at screening or within 3 months prior to first dose of program treatment unless:

1. RNA test negative
2. Successful anti-viral treatment followed by a negative HCV RNA test after a washout period of at least 4 weeks
7. Evidence of Active Bleeding requiring intervention
8. Currently Active Graft-versus-host disease (GvHD)
9. Known Hypersensitivity to the active substance or to any of the excipients
10. Previous progression on belantamab mafodotin
11. Active infection requiring treatment
12. Previous participation in DREAMM-7 or DREAMM-8 clinical trials

Treatment, groups and participation

The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.

Assignment

Not reported

Masking

Not reported

What researchers are measuring

Outcome measures describe what is being studied. They are not proof that a treatment works.

Research locations (0)

The overall study status and a local site’s status can differ. Confirm that location’s availability before traveling.

No locations are listed. Use the official study contact.

Study team and timeline

Lead sponsor

GlaxoSmithKline

Study start

Not reported

Primary completion

Not reported

Study completion

Not reported

First posted

Dec 4, 2018 Actual

Last updated

Nov 10, 2026 Actual

Official study contacts

No central contact is listed. Check the locations and the official record.