Oxidation Rates of the Different Substrates During Exercise in Children and Adolescents With Juvenile Idiopathic Arthritis. Case-control Study and Cases Treated / Cases Not Treated With Anti-TNFα
Juvenile Idiopathic Arthritis
What this study involves
The registry does not currently label this study as recruiting. Ask about its status before planning a screening visit.
- Study type
- Interventional
- Phase
- Not applicable
- Age range
- 8 years - 18 years
- Sex eligible
- All sexes
- Healthy volunteers
- Accepted
- Participants
- 76 Estimated
These are starting points, not an eligibility decision. The research team must review the full requirements.
About the research
During exercise, energy comes mainly from carbohydrates and lipids. The relative contribution of lipids and glucose as energy substrates to exercise depends on the parameters of the exercise (duration, intensity and level of training) and the physiological conditions of the subject.
Inflammatory diseases such as juvenile idiopathic arthritis (JIA) are treated, for the most severe forms, by biotherapies. These treatments target certain pro-inflammatory cytokines including TNFα. In adults with rheumatoid arthritis several studies have shown that treatment with anti-TNFα increases insulin sensitivity. There is no data on the oxidation of energy substrates during exercise in children and adolescents with AJI, nor on the impact of anti-TNFα treatments on the oxidation of energetic substrates in children.
Investigators hypothesize that, compared to healthy children, children with JIA should exhibit altered oxidation of energy substrates at rest and submaximal physical exercise due to physical deconditioning and inflammation. In addition, those treated with anti-TNFα should have an oxidation profile of energy substrates at exercise different from that of patients not treated with anti-TNFα. Investigators also hypothesize that anti-TNFα treatments modify the contribution of energy chains (aerobic, anaerobic and anaerobic alactic) during the exercise.
Read the full description
Annual evaluation by Lipoxmax test and Wingate anaerobic test (WAnT) during 3 years or until the transition from pediatric to adult care.
For healthy volunteer, only one lipaxmax and Wingate test.
Who may be able to participate?
The list below is the sponsor’s full registry wording. It can include conditions, prior treatment, test results and other requirements. A match in search does not mean you qualify.
Inclusion Criteria:
- Children with juvenile idiopathic arthritis
Exclusion Criteria:
- active infection
- BMI \> 25
- Systemic corticosteroid within last 3 months
Treatment, groups and participation
The registry may describe treatments and study duration without a complete visit calendar. Ask the study team for the exact schedule, procedures, risks, costs and alternatives. Keep your usual care plan unless your treating clinician tells you otherwise.
- Assignment
- Not randomized
- Masking
- Not reported
patients treated withTNF blockade
22 patients treated with TNF blockade
Other: anti-TNFα
patients without TNF blockade
22 patients without TNF blockade
Other: anti-TNFα
healthy subjects
22 matched healthy subjects by pubertal stage and sex
Other: anti-TNFα
anti-TNFα OTHER
Not reported in this registry record.
What researchers are measuring
Outcome measures describe what is being studied. They are not proof that a treatment works.
Primary measures
Percentage variation of the maximal fat oxidative rate during an exercise between JIA and healthy children. Timing:
Time frame: at day 1 (first test)
Not reported in this registry record.
Secondary measures
Percentage variation of substrates oxidative crossing point during an exercise.
Time frame: at day 1
Not reported in this registry record.
Description of the contribution of energy systems during supra-maximal physical exercise
Time frame: at day 1 (first test)
Description of the contribution of energy systems during supra-maximal physical exercise in patients with JIA according to JIA subtype, treatments, age, pubertal status, disease status
Review the complete result tables and limitations in the official record.
Open official results ↗Research locations (1)
The overall study status and a local site’s status can differ. Confirm that location’s availability before traveling.
1 locations
CHU Clermon-FerrandClermont-Ferrand, FranceStatus unknown
Study team and timeline
- Lead sponsor
- University Hospital, Clermont-Ferrand
- Study start
- Jan 17, 2017 Actual
- Primary completion
- Jun 22, 2019 Actual
- Study completion
- Mar 22, 2021 Actual
- First posted
- Nov 30, 2016 Estimated
- Last updated
- Nov 10, 2026 Actual
Official study contacts
No central contact is listed. Check the locations and the official record.
Official study title
Oxidation Rates of the Different Substrates During Exercise in Children and Adolescents With Juvenile Idiopathic Arthritis. Case-control Study and Cases Treated / Cases Not Treated With Anti-TNFα
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Source: ClinicalTrials.gov API v2. Information is submitted by sponsors and investigators. NLM does not approve the safety or science of all listed studies. Registry disclaimer.
Retrieved: Nov 12, 2026 · Last registry update: Nov 10, 2026