Acute Blood Flow Restriction Walking on Immune Cell Phenotype and Function
Type 2 Diabetes
De qué trata este estudio
El registro indica que este estudio recluta participantes. La disponibilidad puede variar por centro.
- Tipo de estudio
- De intervención
- Fase
- No aplica
- Rango de edad
- 19 años - 64 años
- Sexo admitido
- Todos los sexos
- Voluntarios sanos
- No aceptados
- Participantes
- 20 Estimado
Estos son puntos de partida, no una decisión de elegibilidad. El equipo debe revisar todos los requisitos.
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Acerca de la investigación
To conduct a randomized control trial to determine the impact of acute blood flow restriction treadmill walking on immune cell counts, function, and phenotype in adults living with type 2 diabetes.
Leer la descripción completa
Participants will be randomized to a regular treadmill walking condition or treadmill walking with blood flow restriction (BFR) condition. In both groups participants will complete 32 minutes of treadmill walking at a speed and grade that elicit 40-50% heart rate reserve. In the BFR group the cuffs will be inflated based on each participants individualized limb occlusion pressure (LOP). The cuffs will remain inflated for the entire session but will deflate for 1 minute every 10 minutes based on safety recommendations. The percentage of LOP will 60%. Blood samples will be obtained pre-exercise (PRE), during the final 2 minutes of the final occlusion cycle (OCC), and 3 minutes into the recovery period post-exercise (POST) to measure outcomes.
¿Quién podría participar?
La lista siguiente contiene el texto del patrocinador. Puede incluir condiciones, tratamientos previos, resultados de pruebas y otros requisitos. Aparecer en tu búsqueda no significa que califiques.
Inclusion Criteria:
- Aged 19-64 years
- Diagnosed with type 2 diabetes with current HbA1c 5.7-9.0%
- Completing \<150 minutes of moderate-vigorous physical activity per week.
Exclusion Criteria:
- Chronic musculoskeletal condition or recent (within 2 years) cardiovascular event preventing participation in exercise.
- Unstable type 2 diabetes medication of the last 3 months
- Absolute contraindications to BFR (i.e., peripheral vascular disease)
- A self-reported diagnosis of low iron concentrations, anemia, or being treated for these conditions
- A diagnosis of any red blood cell-altering condition (i.e., sickle cell anemia, poikilocytosis)
- Currently living with any cardiovascular disease, which would impact the ability to participate in exercise safely
- Currently prescribed any medication which would impact the ability to use a heart rate monitor to accurately track intensity
Tratamiento, grupos y participación
El registro puede describir tratamientos y duración sin incluir un calendario completo. Pide al equipo las visitas, procedimientos, riesgos, costos y alternativas. Mantén tu atención habitual salvo que tu médico te indique un cambio.
- Asignación
- Asignación al azar
- Enmascaramiento
- Sin enmascaramiento
Treadmill walking with blood flow restriction
Treadmill walking with blood flow restriction.
Other: Exercise with BFR
Treadmill Walking
Treadmill walking.
Other: Exercise
Exercise with BFR OTHER
Participants will complete 32 minutes of treadmill walking at a speed and grade that elicit 40-50% heart rate reserve. The cuffs will be inflated based on each participants individualized limb occlusion pressure (LOP). The cuffs will remain inflated for the entire session but will deflate for 1 minute every 10 minutes based on safety recommendations. The percentage of LOP will 60%.
Exercise OTHER
Participants will complete 32 minutes of treadmill walking at a speed and grade that elicit 40-50% heart rate reserve.
Qué evalúan los investigadores
Estas medidas indican qué se estudia. No prueban que un tratamiento funcione.
Medidas principales
Change in white blood cell count before, during, and after exercise.
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The white blood cell count will be measured using a hematology analyzer before, during, and after exercise.
Medidas secundarias
Change in monocyte count before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The monocyte count will be measured using a hematology analyzer before, during, and after exercise.
Change in neutrophil count before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The neutrophil count will be measured using a hematology analyzer before, during, and after exercise.
Change in eosinophil count before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The eosinophil count will be measured using a hematology analyzer before, during, and after exercise.
Change in CD66b+ expression before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The CD66b+ expression will be measured using flow cytometry before, during, and after exercise.
Change in CD11b+ expression before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The CD11b+ expression will be measured using flow cytometer before, during, and after exercise
Change in CD63+ expression before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The CD63+ expression will be measured using flow cytometry before, during, and after exercise.
Change in % of classical monocytes before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The % of classical monocytes will be measured using flow cytometry before, during, and after exercise.
Change in % of intermediate monocytes before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The % of intermediate monocytes will be measured using flow cytometry before, during, and after exercise.
Change in % of non-classical monocytes before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The % of non-classical monocytes will be measured using flow cytometry before, during, and after exercise.
Change in TLR-4 expression on classical monocytes before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The TLR-4 expression on classical monocytes will be measured using flow cytometry before, during, and after exercise.
Change in TLR-4 expression on intermediate monocytes before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The TLR-4 expression on intermediate monocytes will be measured using flow cytometry before, during, and after exercise.
Change in TLR-4 expression on non-classical monocytes before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The TLR-4 expression on non-classical monocytes will be measured using flow cytometry before, during, and after exercise.
Change in plasma IL-6 before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The plasma IL-6 concentration will be measured using a multiplex assay before, during, and after exercise
Change in plasma IL-10 before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The plasma IL-10 concentration will be measured using a multiplex assay before, during, and after exercise.
Change in plasma TNF-α before, during, and after exercise
Plazo: Pre-exercise, during 32 minute of exercise, immediately post-exercise
The plasma TNF-α concentration will be measured using a multiplex assay before, during, and after exercise
Change in 4-h LPS-induced TNF-α before and after exercise
Plazo: Pre-exercise, immediately post-exercise
The LPS-induced TNF-α concentration will be measured from whole-blood culture supernatant using an ELISA before and after exercise.
Change in 4-h LPS+IL10-induced TNF-α before and after exercise
Plazo: Pre-exercise, immediately post-exercise
The LPS+IL10-induced TNF-α concentration will be measured from whole-blood culture supernatant using an ELISA before and after exercise.
Revisa las tablas completas y sus limitaciones en el registro oficial.
Abrir resultados oficiales ↗Centros de investigación (1)
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1 centros
University of British Columbia OkanaganKelowna, British Columbia, CanadaReclutando
Equipo y fechas
- Patrocinador principal
- University of British Columbia
- Inicio del estudio
- 11 feb 2026 Real
- Finalización primaria
- 31 dic 2027 Estimado
- Finalización del estudio
- 31 dic 2027 Estimado
- Primera publicación
- 10 nov 2026 Real
- Última actualización
- 10 nov 2026 Real
Contactos oficiales del estudio
Título oficial del estudio
Impact of Acute Blood Flow Restriction Walking on Immune Cell Phenotype and Function in Adults withT2D
Consulta a Wellness Clinical Research
Tu mensaje va a WCR, incluso si otra organización realiza este estudio. WCR puede orientarte, pero podría no realizar este estudio, tener acceso a su equipo ni poder inscribirte.
Fuente: API v2 de ClinicalTrials.gov. Patrocinadores e investigadores envían la información. La NLM no aprueba la seguridad ni la ciencia de todos los estudios registrados. Aviso del registro.
Consultado: 11 nov 2026 · Última actualización del registro: 10 nov 2026