Effects of Flavonoid Foods on Carbonyl Stress
Human Health · Flavonoids · Carbonyl Stress
De qué trata este estudio
El registro indica que este estudio recluta participantes. La disponibilidad puede variar por centro.
- Tipo de estudio
- De intervención
- Fase
- No aplica
- Rango de edad
- 25 años - 70 años
- Sexo admitido
- Todos los sexos
- Voluntarios sanos
- Aceptados
- Participantes
- 36 Estimado
Estos son puntos de partida, no una decisión de elegibilidad. El equipo debe revisar todos los requisitos.
Las explicaciones y la navegación están en español. Los textos proporcionados por el registro, incluidos títulos, resúmenes y criterios, se conservan en su idioma original. Puedes pedir orientación en español a WCR.
Acerca de la investigación
This randomized crossover study will compare low- and high-flavonoid diets in healthy adults to identify flavonoid-derived biomarkers in urine and plasma. Using targeted liquid chromatography-mass spectrometry (LC-MS) metabolomics, researchers will measure known and novel flavonoid metabolites and evaluate whether a higher flavonoid intake reduces carbonyl stress markers, including reactive carbonyl species (RCS) and advanced glycation end products (AGEs).
Leer la descripción completa
Biomarkers of flavonoids and flavonoid-rich foods are needed to monitor diets. Monitoring diets and associating dietary patterns with health risks and outcomes is an essential step in the research process. The goal of this study is to determine the time- and dose-dependent formation of novel flavonoid metabolites in urine and plasma samples by conducting a randomized crossover trial of two dietary interventions with low (\~140 mg flavonoids/day) and high (\~420 mg flavonoids/day) flavonoid diets among healthy individuals.
Foods with high or low flavonoid content will be incorporated into participants' usual diets. Liquid chromatography-mass spectrometry (LCMS)-based targeted metabolomics will be used to assess flavonoid metabolites, including novel RCS-conjugated and oxidized flavonoid metabolites, and to determine whether consuming a flavonoid-rich diet will lead to a decrease in carbonyl stress as measured by RCS and related advanced glycation end products (AGEs). Investigators will determine the changes in the major RCS and related AGEs after each intervention period using LCMS and examine the relationship between changes in RCS and AGEs and the formation of flavonoid RCS conjugates
¿Quién podría participar?
La lista siguiente contiene el texto del patrocinador. Puede incluir condiciones, tratamientos previos, resultados de pruebas y otros requisitos. Aparecer en tu búsqueda no significa que califiques.
Inclusion Criteria:
- Age 25-70 years
- BMI between 18 and 30
- Have no known allergy to test food
- Have no known allergies to green tea, apples, blueberries, soy milk, or pineapples
- Be not engaging in high-intensity exercise
- Having blood and urine clinical tests in the normal range.
- Be not taking antibiotics for six months
- Be not currently taking medication
- No taking any prescription drugs
- All flavonoid-enriched supplements should be avoided. The flavonoid-enriched supplements list includes soy isoflavones, Lipo-Flavonoid, Citrus Bioflavonoids Complex, Super Flavonoids, Super Antioxidants, Quercetin Supplement, Essential-C, flavonoids, and milk thistle. Also other flavonoid supplements, including but not limited to luteolin, Rutin, etc.
- No drugs or supplements within three weeks of the experiment
- Be nonsmoking
- Have no alcoholic intoxication
- No alcoholic addiction
- \< 3-4 drinks per week (less than 2 glasses (300 mL) per drink)
- No alcohol within three weeks of the experiment
- Have no extended exposure to industrial wastes
Exclusion Criteria:
- Disease: gout, heart disease, peripheral vascular disease, degenerative kidney, degenerative liver, diabetes, GI disorders, or endocrine disorders
- Cancer patients
- Currently diagnosed cancer patients will be excluded.
- Medication-free for \>2 years could be considered.
Tratamiento, grupos y participación
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- Asignación
- Asignación al azar
- Enmascaramiento
- Sin enmascaramiento
High-Flavonoid Diet, Then Low-Flavonoid Diet
All participants will first complete a 2-week low-flavonoid wash-in period. Participants in this sequence will then consume the high-flavonoid diet for 3 weeks, complete a 3-week low-flavonoid washout period, and then consume the low-flavonoid diet for 3 weeks.
Dietary Supplement: High-Flavonoid Diet · Dietary Supplement: Low-Flavonoid Diet
Low-Flavonoid Diet Followed by High-Flavonoid Diet
All participants will first complete a 2-week low-flavonoid wash-in period. Participants in this sequence will then consume the low-flavonoid diet for 3 weeks, complete a 3-week low-flavonoid washout period, and then consume the high-flavonoid diet for 3 weeks.
Dietary Supplement: High-Flavonoid Diet · Dietary Supplement: Low-Flavonoid Diet
High-Flavonoid Diet DIETARY_SUPPLEMENT
Participants will consume the high-flavonoid diet daily for 3 weeks. The diet includes 1 Red Delicious apple (approximately 160 g), freeze-dried whole blueberry powder (25 g), soy milk (240 mL), and decaffeinated Lipton green tea ( 2 g tea leaves), providing approximately 420 mg flavonoids per day.
Low-Flavonoid Diet DIETARY_SUPPLEMENT
Participants will consume the low-flavonoid diet daily for 3 weeks. The diet includes 1/3 of Red Delicious, 107 g of pineapple; 8.3 g of blueberry powder plus 16.7 g of blueberry placebo powder; 80 mL of soy milk plus 160 mL of 2% low-fat milk; and 0.67 g tea leaves, providing approximately 140 mg flavonoids per day.
Qué evalúan los investigadores
Estas medidas indican qué se estudia. No prueban que un tratamiento funcione.
Medidas principales
Plasma and Urine Flavonoid Metabolites
Plazo: After the 3-week dietary intervention period.
Change in plasma and urine concentrations of flavonoid metabolites, including reactive carbonyl species (RCS)-conjugated flavonoid metabolites, measured by liquid chromatography-mass spectrometry (LC-MS).
Medidas secundarias
Association Between Carbonyl Stress Biomarkers and Flavonoid RCS Conjugates
Plazo: After the 3-week dietary intervention
Association between changes in urinary reactive carbonyl species and the formation of flavonoid RCS-conjugated metabolites measured by liquid chromatography-mass spectrometry (LC-MS).
Revisa las tablas completas y sus limitaciones en el registro oficial.
Abrir resultados oficiales ↗Centros de investigación (1)
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1 centros
North Carolina Agriculture and Technical State University/ NRI BuildingKannapolis, North Carolina, United StatesReclutando
Equipo y fechas
- Patrocinador principal
- North Carolina Agriculture & Technical State University
- Inicio del estudio
- 2 sept 2026 Real
- Finalización primaria
- 15 oct 2027 Estimado
- Finalización del estudio
- 31 dic 2027 Estimado
- Primera publicación
- 17 ago 2026 Real
- Última actualización
- 10 nov 2026 Real
Contactos oficiales del estudio
Título oficial del estudio
Effects of Flavonoid-rich Foods on Carbonyl Stress
Consulta a Wellness Clinical Research
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Fuente: API v2 de ClinicalTrials.gov. Patrocinadores e investigadores envían la información. La NLM no aprueba la seguridad ni la ciencia de todos los estudios registrados. Aviso del registro.
Consultado: 12 nov 2026 · Última actualización del registro: 10 nov 2026