Activo, sin reclutamientoNCT07745907Registro de ClinicalTrials.gov

A Phase 1 Trial of AMG 691 in Healthy Chinese and Japanese Volunteers

Healthy Participants

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LO ESENCIAL

De qué trata este estudio

El registro no identifica actualmente este estudio como reclutando. Consulta su estado antes de planificar una evaluación.

Tipo de estudio: De intervención
Fase: Fase 1
Rango de edad: 18 años - 60 años
Sexo admitido: Todos los sexos
Voluntarios sanos: Aceptados
Participantes: 28 Estimado

Estos son puntos de partida, no una decisión de elegibilidad. El equipo debe revisar todos los requisitos.

Las explicaciones y la navegación están en español. Los textos proporcionados por el registro, incluidos títulos, resúmenes y criterios, se conservan en su idioma original. Puedes pedir orientación en español a WCR.

Acerca de la investigación

The trial is designed to evaluate the pharmacokinetics, safety, tolerability, and immunogenicity of AMG 691 in healthy Chinese and Japanese participants

¿Quién podría participar?

La lista siguiente contiene el texto del patrocinador. Puede incluir condiciones, tratamientos previos, resultados de pruebas y otros requisitos. Aparecer en tu búsqueda no significa que califiques.

Inclusion Criteria:

Healthy male or female participants, 18 to 60 years of age.
First-generation Chinese ancestry (born in China, Hong Kong, Taiwan, or Macau with 2 Chinese parents and 4 Chinese grandparents) or first-generation Japanese ancestry (born in Japan with 2 Japanese parents and 4 Japanese grandparents).
Body mass index (BMI) 18.0 to 30.0 kg/m\^2 (inclusive) and body weight ≥40 kg.
In good general health based on medical history, physical examination, vital signs, electrocardiogram (ECG), and clinical laboratory evaluations.
Female participants must not be pregnant or breastfeeding.
Participants of reproductive potential must agree to follow protocol-specified contraception requirements.
Willing to maintain usual diet and physical activity regimen throughout study participation.

Exclusion Criteria:

Clinically significant medical condition, disease, or abnormal finding that could interfere with study participation or interpretation of results.
Clinically significant ECG abnormalities
Clinically significant abnormal blood pressure or pulse rate at screening/check-in.
History of malignancy (except adequately treated in situ cervical cancer or non-melanoma skin cancer \>5 years before dosing).
Deep vein thrombosis or pulmonary embolism within 3 months prior to check-in.
History of hypersensitivity/anaphylaxis to biologic therapies, mammalian-derived products, or AMG 691 excipients.
Active, chronic, recurrent, or unresolved infection; history of severe infection requiring intravenous (IV) antibiotics within the past 3 years.
Positive or indeterminate QuantiFERON-TB Gold test.
Untreated or unresolved helminth parasitic infection.
History of immunodeficiency.
Receipt of live or live-attenuated vaccines within 12 weeks before check-in or planned during the study.
Estimated glomerular filtration rate (eGFR) \<70 mL/min/1.73 m\^2.
Alanine Aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, or direct bilirubin \>1.5 × Upper Limit Normal (ULN).
Positive screening tests for human immunodeficiency virus (HIV), hepatitis B, or hepatitis C infection. Hepatitis B serology consistent with prior vaccination is permitted.
Use of prohibited prescription, over-the-counter, herbal, vitamin, or dietary supplement products within 30 days (or 5 half-lives) before enrollment, unless approved by the investigator.
History of illicit drug use within 1 year, positive drug screen, or unwillingness to abstain from illicit drugs/cannabinoids during the study.
Use of tobacco or nicotine-containing products within 6 months prior to check-in.
History of alcohol abuse or excessive alcohol consumption.
History of non-suicidal self-injury within 5 years or unstable major depressive disorder/other severe psychiatric disorder within 2 years.
Participation in another investigational drug study within 90 days (or 5 half-lives) prior to check-in.
Previous exposure to AMG 691.
Recent donation of blood, plasma, or platelets.
Any participant considered unsuitable by the investigator or unwilling to comply with study restrictions.

Entiende la evaluación inicial

Tratamiento, grupos y participación

El registro puede describir tratamientos y duración sin incluir un calendario completo. Pide al equipo las visitas, procedimientos, riesgos, costos y alternativas. Mantén tu atención habitual salvo que tu médico te indique un cambio.

Asignación: Asignación al azar
Enmascaramiento: Sin enmascaramiento

Cohort 1

Chinese participants will receive AMG 691 at the Level A dose administered subcutaneously (SC)

Drug: AMG 691

Cohort 2

Japanese participants will receive AMG 691 at the Level A dose administered SC

Drug: AMG 691

Cohort 3

Chinese participants will receive AMG 691 at the Level B dose administered SC

Drug: AMG 691

Cohort 4

Japanese participants will receive AMG 691 at the Level B dose administered SC

Drug: AMG 691

AMG 691 DRUG

AMG 691 will be administered subcutaneously

Prepara tus preguntas

Qué evalúan los investigadores

Estas medidas indican qué se estudia. No prueban que un tratamiento funcione.