A Comprehensive Assessment of Altered Embodiment in Individuals With Spinal Cord Injury
Spinal Cord Injuries (SCI)
De qué trata este estudio
El registro no identifica actualmente este estudio como reclutando. Consulta su estado antes de planificar una evaluación.
- Tipo de estudio
- Observacional
- Fase
- No aplica / no indicada
- Rango de edad
- 18 años - 65 años
- Sexo admitido
- Todos los sexos
- Voluntarios sanos
- Aceptados
- Participantes
- 80 Real
Estos son puntos de partida, no una decisión de elegibilidad. El equipo debe revisar todos los requisitos.
Las explicaciones y la navegación están en español. Los textos proporcionados por el registro, incluidos títulos, resúmenes y criterios, se conservan en su idioma original. Puedes pedir orientación en español a WCR.
Acerca de la investigación
Spinal cord injury (SCI) occurs when trauma or other factors damage the spinal cord, disrupting the flow of sensory information from the body to the brain. This interruption can interfere with embodiment-the body awareness and physical sensations processed by the brain-sometimes leading to a phenomenon called disembodiment.
For people with SCI, disembodiment may appear as unusual body sensations, like feeling that a limb is in a different position than it actually is. Such changes in body awareness can impact daily life, mental health, and rehabilitation outcomes.
Despite its importance, the study of embodiment in SCI remains limited. This project aims to explore how SCI alters embodiment, focusing on its specific characteristics, the effects on daily life, and the underlying brain activity as measured by functional magnetic resonance imaging (fMRI). Both people with and without SCI will participate.
Procedure: Participants will complete a single examination lasting 2 to 2.5 hours, including approximately 55 minutes in the MRI scanner (with preparation and follow-up).
¿Quién podría participar?
La lista siguiente contiene el texto del patrocinador. Puede incluir condiciones, tratamientos previos, resultados de pruebas y otros requisitos. Aparecer en tu búsqueda no significa que califiques.
Inclusion Criteria for all participants:
- Age between 18 and 60
- Normal or corrected-to-normal visual acuity
- German or Italian native speaker
Additional Inclusion Criteria only for individuals with SCI:
- Diagnosis of traumatic spinal cord injury
- Lesion level below T1 (first thoracic vertebra)
- Time since injury \>= 12 months
- Residual sensation on the upper leg (sensory capability of 1 or higher on at least one leg in the dermatomes L2 and L3 for both light touch and pin prick).
Exclusion Criteria for all participants:
- Pregnancy or breastfeeding
- Diagnosis of other psychiatric or neurological disorders (e.g. epilepsy, tumor in the central nervous system)
- Confirmed diagnosis of alcohol and/or drug abuse with active consumption within the last 6 months
- Confirmed diagnosis of traumatic brain injury, intended as visible changes in the brain diagnosed by a radiologist
- Stroke
- Inability to perform study procedures (e.g. inability to consent)
Additional Exclusion Criteria for both HC and SCI undergoing the fMRI procedure:
- Active medical devices (e.g. cardiac pacemaker)
- Inability to perform study procedures (e.g. claustrophobia)
Población del estudio
Individuals with spinal cord injury and healthy controls.
Entiende la evaluación inicialTratamiento, grupos y participación
El registro puede describir tratamientos y duración sin incluir un calendario completo. Pide al equipo las visitas, procedimientos, riesgos, costos y alternativas. Mantén tu atención habitual salvo que tu médico te indique un cambio.
- Asignación
- No informado
- Enmascaramiento
- No informado
Individuals with SCI - Behavioral assessment
15 individuals with SCI will perform a comprehensive behavioral assessment of embodiment (see "Interventions"). A clinical assessment of sensory-motor symptoms will also be carried out.
Behavioral: Behavioral assessment
Individuals with SCI - Behavioral assessment and fMRI
25 individuals with SCI will perform a comprehensive behavioral assessment of embodiment and neural correlates of embodiment will be explored by means of an fMRI procedure (see "Interventions"). A clinical assessment of sensory-motor symptoms will also be carried out.
Behavioral: Behavioral assessment · Behavioral: Functional Magnetic Resonance Imaging (fMRI)
Healthy controls - Behavioral assessment
15 healthy controls will perform a comprehensive behavioral assessment of embodiment (see "Interventions").
Behavioral: Behavioral assessment
Healthy controls - Behavioral assessment and fMRI
25 individuals with SCI will perform a comprehensive behavioral assessment of embodiment and neural correlates of embodiment will be explored by means of an fMRI procedure (see "Interventions").
Behavioral: Behavioral assessment · Behavioral: Functional Magnetic Resonance Imaging (fMRI)
Behavioral assessment BEHAVIORAL
A comprehensive behavioral assessment of embodiment and its effect on daily living, taking into account pain, interoception, emotions and anxiety, sleep quality, life satsfaction and cognition.
Functional Magnetic Resonance Imaging (fMRI) BEHAVIORAL
Neural mechanisms of embodiments will be explored with MRI sequences including structural MRI, resting-state and task-based fMRI of the head.
The task will be a modified version of the rubber hand illusion, previously used to asess embodiment. Participants will be required to lay in the MRI with their legs bended upright and a screen placed at the level of their hips, which will show a pair of legs. The participant's leg will be stroked with a paintbrush while the image on the screen will be showing the virtual legs being stroked. Participants will be required to report how strongly they perceive the virtual legs as their own, as a measure of embodiment.
Qué evalúan los investigadores
Estas medidas indican qué se estudia. No prueban que un tratamiento funcione.
Medidas principales
Score on the Body Feelings and Illusions questionnaire (BoFI)
Plazo: Baseline
A questionnaires that assess different dimensions of embodiment and disembodiment.
Medidas secundarias
Brain activity
Plazo: Baseline
Brain activity defined as changes in oxygen levels in the blood during the execution of the embodiment task, and at rest.
Strenght of the embodiment illusion
Plazo: Baseline
Strenght of the embodiment illusion during the fMRI procedures, measured through a Likert scale.
Qualitative assessment of embodiment
Plazo: Baseline
Qualitative assessment of the experience of embodiment by means of a semi-structured interview.
Score on the WHO Disability Assessment Scale (WHODAS-II)
Plazo: Baseline
A scale that assesses activity limitation and participation restriction in the daily life due to disability.
Pain severity
Plazo: Baseline
Intensity of pain measured on a visual analogue scale.
Score on the Positive and Negative Affect Schedule (PANAS)
Plazo: Baseline
A scale which measures positive and negative sensations over the course of the last week.
Anxiety score on the Hospital Anxiety and Depression Scale (HADS)
Plazo: Baseline
A scale the assesses the presence and the intensity of anxiety and depressive symptoms.
Depression score on the Hospital Anxiety and Depression Scale (HADS)
Plazo: Baseline
A scale the assesses the presence and the intensity of anxiety and depressive symptoms.
Score on the Pittsburgh Sleep Quality Index
Plazo: Baseline
A questionnaire assessing the quality of sleep.
Score on the Multidimensional Assessment of Interoceptive Awareness (MAIA)
Plazo: Baseline
A questionnaire assessing interoceptive awarness.
Score on the Inclusion of Others in the Self test (IOS)
Plazo: Baseline
A questionnaire assessing the relationship of the individual self with other entities (e.g., the body, the famiy, the society).
Score on the Montreal Cognitive Assessment (MoCA)
Plazo: Baseline
A test assessing cognitive functions such as memory, attention, language, and executive functions.
Score on the Satisfaction with Life Scale (SLS)
Plazo: Baseline
A scale assessing satisfaction in life.
Motor symptoms severity
Plazo: Baseline
Motor symptoms severity (from level A to E) based on the International Standards for Neurological Classification of spinal cord injury (ISNCSCI)
Demographics
Plazo: Baseline
Demographic information such as age, sex and education level, as well as time since injury.
Revisa las tablas completas y sus limitaciones en el registro oficial.
Abrir resultados oficiales ↗Centros de investigación (1)
El estado general puede diferir del estado de un centro. Confirma la disponibilidad antes de trasladarte.
1 centros
Swiss Paraplegic ResearchNottwil, Canton of Lucerne, SwitzerlandEstado desconocido
Equipo y fechas
- Patrocinador principal
- Swiss Paraplegic Research, Nottwil
- Inicio del estudio
- 4 jun 2025 Real
- Finalización primaria
- 30 jul 2026 Real
- Finalización del estudio
- 31 jul 2026 Real
- Primera publicación
- 14 nov 2024 Real
- Última actualización
- 10 nov 2026 Real
Contactos oficiales del estudio
No hay un contacto central indicado. Revisa los centros y el registro oficial.
Título oficial del estudio
A Comprehensive Assessment of Altered Embodiment in Individuals With Spinal Cord Injury
Consulta a Wellness Clinical Research
Tu mensaje va a WCR, incluso si otra organización realiza este estudio. WCR puede orientarte, pero podría no realizar este estudio, tener acceso a su equipo ni poder inscribirte.
Fuente: API v2 de ClinicalTrials.gov. Patrocinadores e investigadores envían la información. La NLM no aprueba la seguridad ni la ciencia de todos los estudios registrados. Aviso del registro.
Consultado: 12 nov 2026 · Última actualización del registro: 10 nov 2026